| Gene Symbol |
DSE
|
| Entrez Gene |
29940
|
| Alt Symbol |
DSEP, DSEPI, EDSMC2, SART-2, SART2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dermatan sulfate epimerase
|
| Other Description |
DS epimerase|chondroitin-glucuronate 5-epimerase|dermatan-sulfate epimerase|squamous cell carcinoma antigen recognized by T-cells 2
|
| Swissprots |
Q9UL01 Q5R3K6
|
| Accessions |
EAW48229 EAW48230 Q9UL01 AF098066 AAF00087 AK095123 AK128607 BAG54699 AK293872 BAH11619 AK301513 BAH13501 AL832471 BC039245 AAH39245 BC043526 DB282412 DQ891261 ABM82187 DQ894447 ABM85373 XM_011535785 XP_011534087 NM_001080976 NP_001074445 NM_013352 NP_037484
|
| Function |
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. {ECO:0000269|PubMed:16505484}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level). {ECO:0000269|PubMed:10679095}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|
