| Gene Symbol |
RND1
|
| Entrez Gene |
27289
|
| Alt Symbol |
ARHS, RHO6, RHOS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho family GTPase 1
|
| Other Description |
ras homolog gene family, member S|rho-related GTP-binding protein Rho6
|
| Swissprots |
Q92730 A8K9P7
|
| Accessions |
EAW58019 Q92730 AB040147 BAB17851 AF498967 AAM21114 AK124288 AK292762 BAF85451 AL359573 BC026356 AAH26356 N79562 Y07923 CAA69228 NM_014470 NP_055285
|
| Function |
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269|PubMed:11095956}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11940653}; Lipid-anchor {ECO:0000269|PubMed:11940653}; Cytoplasmic side {ECO:0000269|PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11940653}.
|
| Tissue Specificity |
Mostly expressed in brain and liver.
|
| Top Pathways |
Axon guidance
|
![Western Blot: RND1 Overexpression Lysate (Adult Normal) [NBL1-15404] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RND1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2517_RND1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15404-img0002.jpg)