Gene Symbol | RND1 |
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Entrez Gene | 27289 |
Alt Symbol | ARHS, RHO6, RHOS |
Species | Human |
Gene Type | protein-coding |
Description | Rho family GTPase 1 |
Other Description | ras homolog gene family, member S|rho-related GTP-binding protein Rho6 |
Swissprots | Q92730 A8K9P7 |
Accessions | EAW58019 Q92730 AB040147 BAB17851 AF498967 AAM21114 AK124288 AK292762 BAF85451 AL359573 BC026356 AAH26356 N79562 Y07923 CAA69228 NM_014470 NP_055285 |
Function | Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269|PubMed:11095956}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11940653}; Lipid-anchor {ECO:0000269|PubMed:11940653}; Cytoplasmic side {ECO:0000269|PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11940653}. |
Tissue Specificity | Mostly expressed in brain and liver. |
Top Pathways | Axon guidance |
Rnd1 CRISPR/Cas9 KO Plasmid (h) - sc-406603 from Santa Cruz Biotechnology
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Rnd1 HDR Plasmid (h) - sc-406603-HDR from Santa Cruz Biotechnology
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Rnd1 Double Nickase Plasmid (h) - sc-406603-NIC from Santa Cruz Biotechnology
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Rnd1 Double Nickase Plasmid (h2) - sc-406603-NIC-2 from Santa Cruz Biotechnology
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Rnd1 CRISPR Activation Plasmid (h) - sc-406603-ACT from Santa Cruz Biotechnology
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Rnd1 CRISPR Activation Plasmid (h2) - sc-406603-ACT-2 from Santa Cruz Biotechnology
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Rnd1 Lentiviral Activation Particles (h) - sc-406603-LAC from Santa Cruz Biotechnology
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Rnd1 Lentiviral Activation Particles (h2) - sc-406603-LAC-2 from Santa Cruz Biotechnology
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Rnd1 siRNA (h) - sc-106516 from Santa Cruz Biotechnology
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Rnd1 shRNA Plasmid (h) - sc-106516-SH from Santa Cruz Biotechnology
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Rnd1 shRNA (h) Lentiviral Particles - sc-106516-V from Santa Cruz Biotechnology
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RND1 RNAi - H00027289-R01 from Novus Biologicals
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MISSION® esiRNA - EHU046771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18359 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18359 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06976 from Sigma-Aldrich
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RND1 siRNA (Human) - CRH9056 from Cohesion Biosciences
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RND1 - MBS829035 from MyBioSource
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Rnd1 CRISPR/Cas9 KO Plasmid (h2) - sc-406603-KO-2 from Santa Cruz Biotechnology
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Rnd1 HDR Plasmid (h2) - sc-406603-HDR-2 from Santa Cruz Biotechnology
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RND1 shRNA Plasmid (Human) - CHH9056 from Cohesion Biosciences
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RND1 miRNA 3'UTR clone - MiUTR3H-10375 from Creative biogene
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