| Gene Symbol |
PTDSS1
|
| Entrez Gene |
9791
|
| Alt Symbol |
LMHD, PSS1, PSSA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylserine synthase 1
|
| Other Description |
PSS-1|ptdSer synthase 1|serine-exchange enzyme I
|
| Swissprots |
B4DE85 P48651 Q9BUQ5 E5RFC5
|
| Accessions |
EAW91753 EAW91754 P48651 AK293036 BAF85725 AK293513 BAG56996 BC002376 AAH02376 BC004192 AAH04192 BC004390 AAH04390 BC004502 AAH04502 BM459031 D14694 BAA03520 DQ891825 ABM82751 DQ895012 ABM85938 HY087183 NM_001290225 NP_001277154 NM_014754 NP_055569
|
| Function |
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}.
|
| Top Pathways |
Glycerophospholipid metabolism
|
![Western Blot: PTDSS1 Overexpression Lysate (Adult Normal) [NBL1-14925] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PTDSS1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2691_PTDSS1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14925-img0002.jpg)