Gene Symbol | PTDSS1 |
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Entrez Gene | 9791 |
Alt Symbol | LMHD, PSS1, PSSA |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylserine synthase 1 |
Other Description | PSS-1|ptdSer synthase 1|serine-exchange enzyme I |
Swissprots | B4DE85 P48651 Q9BUQ5 E5RFC5 |
Accessions | EAW91753 EAW91754 P48651 AK293036 BAF85725 AK293513 BAG56996 BC002376 AAH02376 BC004192 AAH04192 BC004390 AAH04390 BC004502 AAH04502 BM459031 D14694 BAA03520 DQ891825 ABM82751 DQ895012 ABM85938 HY087183 NM_001290225 NP_001277154 NM_014754 NP_055569 |
Function | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}. |
Top Pathways | Glycerophospholipid metabolism |
PSS1 CRISPR/Cas9 KO Plasmid (h) - sc-404364 from Santa Cruz Biotechnology
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PSS1 HDR Plasmid (h) - sc-404364-HDR from Santa Cruz Biotechnology
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PSS1 Double Nickase Plasmid (h) - sc-404364-NIC from Santa Cruz Biotechnology
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PSS1 Double Nickase Plasmid (h2) - sc-404364-NIC-2 from Santa Cruz Biotechnology
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PSS1 CRISPR Activation Plasmid (h) - sc-404364-ACT from Santa Cruz Biotechnology
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PSS1 CRISPR Activation Plasmid (h2) - sc-404364-ACT-2 from Santa Cruz Biotechnology
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PSS1 Lentiviral Activation Particles (h) - sc-404364-LAC from Santa Cruz Biotechnology
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PSS1 Lentiviral Activation Particles (h2) - sc-404364-LAC-2 from Santa Cruz Biotechnology
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PSS1 siRNA (h) - sc-72365 from Santa Cruz Biotechnology
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PSS1 shRNA Plasmid (h) - sc-72365-SH from Santa Cruz Biotechnology
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PSS1 shRNA (h) Lentiviral Particles - sc-72365-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17660 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17660 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07483 from Sigma-Aldrich
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PTDSS1 siRNA (Human) - CRH6553 from Cohesion Biosciences
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shRNA set against Human PTDSS1 (NM_014754.1) - SHH385884 from Creative biogene
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shRNA set against Human PTDSS1(NM_014754.1) - SHR150234 from Creative biogene
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Human PTDSS1 siRNA - orb267055 from Biorbyt
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PTDSS1 shRNA Plasmid (Human) - CHH6553 from Cohesion Biosciences
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PTDSS1 miRNA 3'UTR clone - MiUTR1H-08410 from Creative biogene
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