WIBG

Gene Symbol WIBG
Entrez Gene 84305
Alt Symbol PYM
Species Human
Gene Type protein-coding
Description within bgcn homolog (Drosophila)
Other Description partner of Y14 and mago|protein wibg homolog
Swissprots Q8IXJ8 B6ZDM5 Q9BRP8 Q8N8E7
Accessions EAW96847 EAW96848 Q9BRP8 AJ459406 CAD30677 AK096922 BAC04897 BC006135 AAH06135 BC008292 BC009627 AAH09627 BC014976 AAH14976 DB466388 NM_001143853 NP_001137325 NM_032345 NP_115721
Function Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.
Top Pathways RNA transport, mRNA surveillance pathway

WIBG (N-13) - sc-169812 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

WIBG (V-14) - sc-169813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WIBG antibody - ab108152 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-WIBG antibody (ab108152) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

Anti-WIBG antibody - ab171014 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-WIBG antibody (ab171014) at 1 µg/ml + Mouse thymus lysate at 10 µg

Anti-WIBG Antibody (aa15-44) - LS-C326360 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (C-Terminus) - LS-C135815 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WIBG antibody LS-C135815 Western blot of 721_B cell lysate.

Anti-WIBG Antibody (aa81-130) - LS-C170340 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (clone 11C5) - LS-C339949 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11C5
IHC of paraffin-embedded Human tonsil using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-WIBG Antibody (aa12-40) - LS-C160622 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WIBG antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervical tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-WIBG Antibody (clone 2C1) - LS-C340033 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C1
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-WIBG Antibody (clone 8D7) - LS-C339991 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8D7
Western blot of extracts (10ug) from 5 different cell lines and 4 human tissue by using anti-WIBG monoclonal antibody (1: HeLa; 2: HepG2; 3: K562; 4: Mcf7; 5: SVT2; 6: Liver; 7: Testis; 8: Brain; 9: Uterus) at 1:200 dilution.

Anti-WIBG Antibody (clone 2C7) - LS-C339994 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C7
Western blot of extracts (10ug) from 5 different cell lines and 4 human tissue by using anti-WIBG monoclonal antibody (1: HeLa; 2: HepG2; 3: K562; 4: Mcf7; 5: SVT2; 6: Liver; 7: Testis; 8: Brain; 9: Uterus) at 1:200 dilution.

Anti-WIBG Antibody (clone 9C7) - LS-C339988 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C7
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-WIBG Antibody (clone 1E10) - LS-C339990 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E10
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).

Anti-WIBG Antibody (clone 5E2) - LS-C339981 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E2
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-WIBG Antibody (aa12-40, AP) - LS-C273601 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (aa12-40, APC) - LS-C273602 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (aa12-40, Biotin) - LS-C273603 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (aa12-40, FITC) - LS-C273604 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (aa12-40, PE) - LS-C273606 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WIBG Antibody (aa12-40, Azide-free, HRP) - LS-C273605 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

WIBG Antibody - NBP1-92596 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WIBG Antibody - NBP1-79834 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: WIBG Antibody [NBP1-79834] - 721_B cell lysate, concentration 0.2-1 ug/ml.

Anti-WIBG antibody produced in rabbit - HPA046200 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WIBG: <B>Cat. No. HPA046200</B>: Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.

Anti-WIBG (46-60) antibody produced in rabbit - SAB1103121 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human WIBG was separated on SDS-PAGE, blotted with Anti-WIBG (46-60) (<B>Cat. No. SAB1103121</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + WIBG immunizing peptide (human, 46-60)
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