| Gene Symbol |
WIBG
|
| Entrez Gene |
84305
|
| Alt Symbol |
PYM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
within bgcn homolog (Drosophila)
|
| Other Description |
partner of Y14 and mago|protein wibg homolog
|
| Swissprots |
Q8IXJ8 B6ZDM5 Q9BRP8 Q8N8E7
|
| Accessions |
EAW96847 EAW96848 Q9BRP8 AJ459406 CAD30677 AK096922 BAC04897 BC006135 AAH06135 BC008292 BC009627 AAH09627 BC014976 AAH14976 DB466388 NM_001143853 NP_001137325 NM_032345 NP_115721
|
| Function |
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.
|
| Top Pathways |
RNA transport, mRNA surveillance pathway
|