WIBG

Gene Symbol	WIBG
Entrez Gene	84305
Alt Symbol	PYM
Species	Human
Gene Type	protein-coding
Description	within bgcn homolog (Drosophila)
Other Description	partner of Y14 and mago|protein wibg homolog
Swissprots	Q8IXJ8 B6ZDM5 Q9BRP8 Q8N8E7
Accessions	EAW96847 EAW96848 Q9BRP8 AJ459406 CAD30677 AK096922 BAC04897 BC006135 AAH06135 BC008292 BC009627 AAH09627 BC014976 AAH14976 DB466388 NM_001143853 NP_001137325 NM_032345 NP_115721
Function	Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WIBG full length protein - ab172179 from Abcam Category Protein Source E. coli Species Human

Human WIBG full length protein - ab98083 from Abcam Category Protein Source E. coli Species Human

WIBG Antibody Blocking Peptide - LS-E429 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WIBG Antibody Blocking Peptide - LS-E22155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WIBG Antibody Blocking Peptide - LS-E22156 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WIBG Protein - NBP1-45288 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

WIBG Recombinant Protein - H00084305-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

WIBG-Antibody-N-term-Blocking-peptide - BP10709a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WIBG Protein (OPPA02396) - OPPA02396 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human WIBG protein - orb81475 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human WIBG protein - orb49574 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

WIBG Blocking Peptide - 33R-4474 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WIBG protein (His tag) - 80R-1397 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

WIBG / PYM (1-240, His-tag) - AR09572PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

WIBG / PYM (1-240, His-tag) - AR09572PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

WIBG / PYM - H00084305-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WIBG / PYM - H00084305-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Partner of Y14 and mago, WIBG, Human, Recombinant - 19-CE29 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

WIBG, 1-204aa, Human, His tag, E.coli - 01-1886 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

WIBG fusion protein - Ag6276 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

WIBG Human - PRPS-871 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human WIBG Protein - BP001743-CE29 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human WIBG Protein - BP001743-PRO-864 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

WIBG Human Protein - GWB-BSP715 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

WIBG, 1-204aa, Recombinant Protein - GWB-P1403L from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

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