| Gene Symbol | AQP3 |
|---|---|
| Entrez Gene | 360 |
| Alt Symbol | AQP-3, GIL |
| Species | Human |
| Gene Type | protein-coding |
| Description | aquaporin 3 (Gill blood group) |
| Other Description | aquaglyceroporin-3|aquaporin 3 (GIL blood group)|aquaporin-3 |
| Swissprots | B2RE16 Q92482 Q6FGW6 Q6FGT2 O00108 D3DRL3 A8K843 |
| Accessions | AAY68214 BAA09077 CCF76945 EAW58500 EAW58501 EAW58502 EAW58503 EAW58504 Q92482 AB001325 BAA19237 AJ493597 CAD38526 AK095363 AK292208 BAF84897 AK303206 BAG64296 AK315760 BAG38113 BC012988 BC013566 AAH13566 BF437236 BT007199 AAP35863 CR541991 CAG46788 CR542025 CAG46822 DA976040 XM_011517864 XP_011516166 NM_004925 NP_004916 |
| Function | Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO:0000250}. |
| Subcellular Location | Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney. |
| Tissue Specificity | Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level. |
| Top Pathways | Vasopressin-regulated water reabsorption |
AQP3 CRISPR/Cas9 KO Plasmid (h) - sc-400636 from Santa Cruz Biotechnology
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AQP3 HDR Plasmid (h) - sc-400636-HDR from Santa Cruz Biotechnology
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AQP3 Double Nickase Plasmid (h) - sc-400636-NIC from Santa Cruz Biotechnology
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AQP3 Double Nickase Plasmid (h2) - sc-400636-NIC-2 from Santa Cruz Biotechnology
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AQP3 CRISPR Activation Plasmid (h) - sc-400636-ACT from Santa Cruz Biotechnology
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AQP3 CRISPR Activation Plasmid (h2) - sc-400636-ACT-2 from Santa Cruz Biotechnology
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AQP3 Lentiviral Activation Particles (h) - sc-400636-LAC from Santa Cruz Biotechnology
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AQP3 Lentiviral Activation Particles (h2) - sc-400636-LAC-2 from Santa Cruz Biotechnology
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AQP3 siRNA (h) - sc-29713 from Santa Cruz Biotechnology
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AQP3 shRNA Plasmid (h) - sc-29713-SH from Santa Cruz Biotechnology
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AQP3 shRNA (h) Lentiviral Particles - sc-29713-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3370 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3370 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06693 from Sigma-Aldrich
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AQP3 siRNA (Human) - CRH0256 from Cohesion Biosciences
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Aquaporin-3 RNAi - H00000360-R01 from Novus Biologicals
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AQP3 - MBS8234657 from MyBioSource
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shRNA set against Human AQP3 (NM_004925.4) - SHH238862 from Creative biogene
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Human Aquaporin 3 siRNA - orb260758 from Biorbyt
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AQP3 shRNA Plasmid (Human) - CHH0256 from Cohesion Biosciences
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AQP3 miRNA 3'UTR clone - MiUTR3H-03169 from Creative biogene
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