MINK1

Gene Symbol MINK1
Entrez Gene 50488
Alt Symbol B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta
Species Human
Gene Type protein-coding
Description misshapen-like kinase 1
Other Description GCK family kinase MINK|MAPK/ERK kinase kinase kinase 6|MEK kinase kinase 6|MEKKK 6|misshapen/NIK-related kinase|mitogen-activated protein kinase kinase kinase kinase 6|serine/threonine protein kinase
Swissprots Q8N4C8 D3DTK3 Q9P2R8 Q5U8Z0 D3DTK4 Q9P1X1
Accessions BAB97271 CAC69813 EAW90398 EAW90399 EAW90400 EAW90401 EAW90402 EAW90403 Q8N4C8 AB035698 BAA90753 AB041926 BAA94838 AB209450 BAD92687 AF218033 AAG17275 AK096610 AL157418 AY775058 AAV41830 BC028888 BC034673 AAH34673 BC094686 BM674875 BQ006038 CA392419 DA653105 DQ891158 ABM82084 DQ894339 ABM85265 XM_005256664 XP_005256721 XM_005256665 XP_005256722 XM_006721530 XP_006721593 XM_006721531 XP_006721594 XM_006721532 XP_006721595 XM_006721533 XP_006721596 XM_006721534 XP_006721597 XM_006721535 XP_006721598 XM_006721536 XP_006721599 XM_006721538 XP_006721601 XM_011523905 XP_011522207 XM_011523906 XP_011522208 XM_011523907 XP_011522209 XM_011523908 XP_011522210 XM_011523909 XP_011522211 NM_001024937 NP_001020108 NM_015716 NP_056531 NM_153827 NP_722549 NM_170663 NP_733763
Function Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. {ECO:0000269|PubMed:15469942}.

MINK1 (E-17) - sc-54964 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MINK1 (E-17): sc-54964. Western blot analysis of MINK1 expression in non-transfected: sc-117752 (A) and human MINK1 transfected: sc-171838 (B) 293T whole cell lysates.

MINK1 (P-15) - sc-54966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MINK1 (P-15): sc-54966. Western blot analysis of MINK1 expression in non-transfected: sc-117752 (A) and human MINK1 transfected: sc-171838 (B) 293T whole cell lysates.

MINK1 (T-20) - sc-54967 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MINK1 (T-20): sc-54967. Western blot analysis of MINK1 expression in non-transfected: sc-117752 (A) and human MINK1 transfected: sc-171838 (B) 293T whole cell lysates.

MINK1 (H-117) - sc-292594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MAP4K6 antibody - ab69563 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAP4K6 antibody (ab69563) at 1/500 dilutionLane 1 : Extracts from COLO cellsLane 2 : Extracts from COLO cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-MAP4K6 antibody - C-terminal - ab154256 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAP4K6 antibody - C-terminal (ab154256) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-MINK1 / MINK Antibody (C-Terminus, Biotin) - LS-C220060 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus, AP) - LS-C220059 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus, APC) - LS-C220061 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus, Azide-free, HRP) - LS-C220063 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus, FITC) - LS-C220062 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus, PE) - LS-C220066 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (aa1-50) - LS-C288945 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (aa575-625) - LS-C288946 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (C-Terminus) - LS-C155287 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: U87-MG 5% SDS PAGE MINK1 / MAP4K6 antibody diluted at 1:1000

Anti-MINK1 / MINK Antibody (C-Terminus) - LS-C330538 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (aa775-825) - LS-C288947 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MINK1 / MINK Antibody (aa755-804) - LS-C109705 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MINK1 / MAP4K6 antibody LS-C109705 Western blot of Transfected 293T cell lysate.

Anti-MINK1 / MINK Antibody (aa401-450) - LS-C119142 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO cells, using MAP4K6 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-MINK1 / MINK Antibody (Internal) IHC-plus™ - LS-A7412 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MINK1 / MAP4K6 antibody LS-A7412 IHC of human hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-MINK1 / MINK Antibody (Internal) IHC-plus™ - LS-A7408 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MINK1 / MAP4K6 antibody LS-A7408 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAP4K6 Antibody - NBP1-22990 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAP4K6 Antibody [NBP1-22990] - Wole cell lysate from HeLa and mouse NIH3T3 cells at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.

MAP4K6 Antibody - NBP1-32766 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAP4K6 Antibody [NBP1-32766] - Sample (30 ug of whole cell lysate) A: Hep G2 7.5% SDS PAGE diluted at 1:1000

MAP4K6 Antibody - NLS7412 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: MAP4K6 Antibody [NLS7412] - Anti-MINK1 / MAP4K6 antibody IHC of human hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAP4K6 Antibody - NBP1-22989 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAP4K6 Antibody [NBP1-22989] - Whole cell lysate from HeLa and mouse NIH3T3 cells. NBP1-22989 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.
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