MINK1

Gene Symbol	MINK1
Entrez Gene	50488
Alt Symbol	B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta
Species	Human
Gene Type	protein-coding
Description	misshapen-like kinase 1
Other Description	GCK family kinase MINK|MAPK/ERK kinase kinase kinase 6|MEK kinase kinase 6|MEKKK 6|misshapen/NIK-related kinase|mitogen-activated protein kinase kinase kinase kinase 6|serine/threonine protein kinase
Swissprots	Q8N4C8 D3DTK3 Q9P2R8 Q5U8Z0 D3DTK4 Q9P1X1
Accessions	BAB97271 CAC69813 EAW90398 EAW90399 EAW90400 EAW90401 EAW90402 EAW90403 Q8N4C8 AB035698 BAA90753 AB041926 BAA94838 AB209450 BAD92687 AF218033 AAG17275 AK096610 AL157418 AY775058 AAV41830 BC028888 BC034673 AAH34673 BC094686 BM674875 BQ006038 CA392419 DA653105 DQ891158 ABM82084 DQ894339 ABM85265 XM_005256664 XP_005256721 XM_005256665 XP_005256722 XM_006721530 XP_006721593 XM_006721531 XP_006721594 XM_006721532 XP_006721595 XM_006721533 XP_006721596 XM_006721534 XP_006721597 XM_006721535 XP_006721598 XM_006721536 XP_006721599 XM_006721538 XP_006721601 XM_011523905 XP_011522207 XM_011523906 XP_011522208 XM_011523907 XP_011522209 XM_011523908 XP_011522210 XM_011523909 XP_011522211 NM_001024937 NP_001020108 NM_015716 NP_056531 NM_153827 NP_722549 NM_170663 NP_733763
Function	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. {ECO:0000269|PubMed:15469942}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MAP4K6 protein fragment - ab55712 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

MINK1 / MINK Antibody Blocking Peptide - LS-E11509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MINK1 / MINK Antibody Blocking Peptide - LS-E29266 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MINK1 / MINK Antibody Blocking Peptide - LS-E29267 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human MAP4K6 Protein - P4724 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

MINK1 Blocking Peptide - 33R-7024 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MINK1 - P4724 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

MINK1 - P5730 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MINK1 fusion protein - ag3795 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MINK1, GST-tagged, Active - MINK1-354H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human MINK1 (Active), GST-tagged - MINK1-1431H from Creative Biomart Category Protein Source Sf9 Cells Species Human

MINK Protein, active, 250 µg - 14-615M from EMD Millipore Category Protein Prices $2,440.00 Sizes 250 µg also available in 10 μg size . (cat#14-615) and in bulk (cat#14-615-K) Source expressed by baculovirus in Sf21 insect cells

Recombinant Human Misshapen-like kinase 1(MINK1) ,partial - CSB-YP818701HU CSB-EP818701HU CSB-BP818701HU CSB-MP818701HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MEKKK6 Blocking Peptide - abx161676 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

MINK1 (transcript variant 3) - TP304403 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human MINK1 His - CSI12097 from Cell Science Prices $615.00 Sizes 10 μg Species Human

MINK Protein, active, 10 µg - 14-615 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed by baculovirus in Sf21 insect cells

MAP4K6 Recombinant Protein Antigen - NBP2-49220PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

MINK12-Antibody-C-term-Blocking-Peptide - BP7914a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MINK1 Peptide, Human - M34GP09525H from Creative Peptides Category Peptide Source Synthetic. Species Human

MEKKK6 Blocking Peptide - CBP4465 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

MINK1 - PK-MINK1-A010 from B-Bridge Category Protein Prices $456.00 Sizes 10 µg

MEKKK6 Blocking Peptide - orb392810 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Bovine, Human, Mouse, Rat

Misshapen-like kinase 1 (MINK1), partial, Recombinant Protein - MBS1418371 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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