| Gene Symbol |
MINK1
|
| Entrez Gene |
50488
|
| Alt Symbol |
B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
misshapen-like kinase 1
|
| Other Description |
GCK family kinase MINK|MAPK/ERK kinase kinase kinase 6|MEK kinase kinase 6|MEKKK 6|misshapen/NIK-related kinase|mitogen-activated protein kinase kinase kinase kinase 6|serine/threonine protein kinase
|
| Swissprots |
Q8N4C8 D3DTK3 Q9P2R8 Q5U8Z0 D3DTK4 Q9P1X1
|
| Accessions |
BAB97271 CAC69813 EAW90398 EAW90399 EAW90400 EAW90401 EAW90402 EAW90403 Q8N4C8 AB035698 BAA90753 AB041926 BAA94838 AB209450 BAD92687 AF218033 AAG17275 AK096610 AL157418 AY775058 AAV41830 BC028888 BC034673 AAH34673 BC094686 BM674875 BQ006038 CA392419 DA653105 DQ891158 ABM82084 DQ894339 ABM85265 XM_005256664 XP_005256721 XM_005256665 XP_005256722 XM_006721530 XP_006721593 XM_006721531 XP_006721594 XM_006721532 XP_006721595 XM_006721533 XP_006721596 XM_006721534 XP_006721597 XM_006721535 XP_006721598 XM_006721536 XP_006721599 XM_006721538 XP_006721601 XM_011523905 XP_011522207 XM_011523906 XP_011522208 XM_011523907 XP_011522209 XM_011523908 XP_011522210 XM_011523909 XP_011522211 NM_001024937 NP_001020108 NM_015716 NP_056531 NM_153827 NP_722549 NM_170663 NP_733763
|
| Function |
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. {ECO:0000269|PubMed:15469942}.
|