| Gene Symbol |
JSRP1
|
| Entrez Gene |
126306
|
| Alt Symbol |
JP-45, JP45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
junctional sarcoplasmic reticulum protein 1
|
| Other Description |
2310032K21Rik|homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45|junctional-face membrane protein of 45 kDa homolog|skeletal muscle sarcoplasmic reticulum protein JP-45
|
| Swissprots |
Q96MG2
|
| Accessions |
EAW69396 Q96MG2 AK056978 BAB71330 AW137573 BC021201 AAH21201 DA897543 DA898560 EU831408 ACE87095 EU831501 ACE86420 NM_144616 NP_653217
|
| Function |
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}.
|
| Subcellular Location |
Sarcoplasmic reticulum membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes. {ECO:0000250}.
|
