Gene Symbol | JSRP1 |
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Entrez Gene | 126306 |
Alt Symbol | JP-45, JP45 |
Species | Human |
Gene Type | protein-coding |
Description | junctional sarcoplasmic reticulum protein 1 |
Other Description | 2310032K21Rik|homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45|junctional-face membrane protein of 45 kDa homolog|skeletal muscle sarcoplasmic reticulum protein JP-45 |
Swissprots | Q96MG2 |
Accessions | EAW69396 Q96MG2 AK056978 BAB71330 AW137573 BC021201 AAH21201 DA897543 DA898560 EU831408 ACE87095 EU831501 ACE86420 NM_144616 NP_653217 |
Function | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
Subcellular Location | Sarcoplasmic reticulum membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes. {ECO:0000250}. |
JP-45 CRISPR/Cas9 KO Plasmid (h) - sc-414266 from Santa Cruz Biotechnology
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JP-45 HDR Plasmid (h) - sc-414266-HDR from Santa Cruz Biotechnology
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JP-45 Double Nickase Plasmid (h) - sc-414266-NIC from Santa Cruz Biotechnology
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JP-45 Double Nickase Plasmid (h2) - sc-414266-NIC-2 from Santa Cruz Biotechnology
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JP-45 CRISPR Activation Plasmid (h) - sc-414266-ACT from Santa Cruz Biotechnology
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JP-45 CRISPR Activation Plasmid (h2) - sc-414266-ACT-2 from Santa Cruz Biotechnology
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JP-45 Lentiviral Activation Particles (h) - sc-414266-LAC from Santa Cruz Biotechnology
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JP-45 Lentiviral Activation Particles (h2) - sc-414266-LAC-2 from Santa Cruz Biotechnology
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JP-45 siRNA (h) - sc-97676 from Santa Cruz Biotechnology
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JP-45 shRNA Plasmid (h) - sc-97676-SH from Santa Cruz Biotechnology
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JP-45 shRNA (h) Lentiviral Particles - sc-97676-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10882 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10882 from Sigma-Aldrich
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JSRP1 siRNA (Human) - CRJ4854 from Cohesion Biosciences
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JSRP1, siRNA - MBS8217995 from MyBioSource
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shRNA set against Human JSRP1 (NM_144616.3) - SHH322239 from Creative biogene
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Human JSRP1 siRNA - orb275355 from Biorbyt
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JSRP1 shRNA Plasmid (Human) - CHJ4854 from Cohesion Biosciences
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JSRP1 miRNA 3'UTR clone - MiUTR3H-10189 from Creative biogene
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