MICU1

Gene Symbol MICU1
Entrez Gene 10367
Alt Symbol CALC, CBARA1, EFHA3, MPXPS
Species Human
Gene Type protein-coding
Description mitochondrial calcium uptake 1
Other Description ara CALC|atopy-related autoantigen CALC|calcium uptake protein 1, mitochondrial|calcium-binding atopy-related autoantigen 1
Swissprots B4DPI1 A8MV96 Q9UFX0 O75785 B5MBY3 B4DJH9 Q9H9N6 Q9BPX6 D3YTJ3 B3KN20
Accessions EAW54457 EAW54458 EAW54459 Q9BPX6 AK022697 BAB14187 AK023318 BAG51182 AK225298 AK225695 AK296086 BAG58841 AK298347 BAG60593 AL117423 CAB55915 BC004190 AAH04190 BC004216 AAH04216 BC016641 AAH16641 BU627477 DB030067 DQ891087 ABM82013 EU176543 ABW03344 Y17711 CAA76830 XM_005269383 XP_005269440 XM_005269384 XP_005269441 XM_005269386 XP_005269443 XM_011539119 XP_011537421 XR_945585 XR_945586 NM_001195518 NP_001182447 NM_001195519 NP_001182448 NM_006077 NP_006068
Function Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes at the outer surface of the mitochondrion inner membrane.
Tissue Specificity Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:9806765}.

CBARA1/MICU1 (D4P8Q) Rabbit mAb - 12524 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4P8Q
Western blot analysis of extracts from various cell lines using CBARA1/MICU1 (D4P8Q) Rabbit mAb.

CBARA1 (D-13) - sc-160210 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CBARA1 (T-14) - sc-160211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CBARA1 (V-13) - sc-160212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CBARA1 antibody - ab102830 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab102830 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab102830, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MICU1 / CBARA1 Antibody (aa59-89, AP) - LS-C253462 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa59-89, APC) - LS-C253464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa59-89, Biotin) - LS-C253465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa210-259) - LS-C205435 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MICU1 / CBARA1 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-MICU1 / CBARA1 Antibody (aa59-89, FITC) - LS-C253466 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa59-89, Azide-free, HRP) - LS-C253467 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa59-89) - LS-C329318 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa59-89, PE) - LS-C253468 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MICU1 / CBARA1 Antibody (aa52-81) - LS-C168349 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of CBAA1 Antibody in K562 cell line lysates (35 ug/lane). CBAA1 (arrow) was detected using the purified antibody.

Anti-MICU1 / CBARA1 Antibody (aa113-126) IHC-plus™ - LS-B9505 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MICU1 / CBARA1 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CBARA1 Antibody - NBP1-86663 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CBARA1 Antibody [NBP1-86663] - Staining of human adrenal gland shows strong cytoplasmic and nuclear positivity in cortical cells.

CBARA1 Antibody - H00010367-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CBARA1 Antibody [H00010367-A01] - Western Blot analysis of CBARA1 expression in Raw 264.7.

ANTI-CBAA1 (N-TERM) antibody produced in rabbit - SAB1304787 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CBAA1 (N-term): <B>Cat. No. SAB1304787</B>: Western blot analysis of CBAA1 Antibody (N-term) in K562 cell line lysates (35 μg/lane).

Anti-MICU1 antibody produced in rabbit - HPA037480 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CBARA1: <B>Cat. No. HPA037480</B>: Immunohistochemical staining of human adrenal gland shows strong cytoplasmic and nuclear positivity in cortical cells.

MICU1 Antibody - C-terminal region (ARP66753_P050) - ARP66753_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CBAA1-Antibody-N-term - AP9682a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CBAA1 Antibody (N-term) (Cat. #AP9682a) in K562 cell line lysates (35ug/lane). CBAA1 (arrow) was detected using the purified Pab.

CBARA1-aa113-126-Antibody-internal-region - AF3517a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3517a (0.5 µg/ml) staining of K562 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CBARA1 Antibody - N-terminal region (OAAB06279) - OAAB06279 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Mitochondrial calcium uptake 1 antibody - GTX53535 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-Mitochondrial calcium uptake 1 antibody used in Western blot. GTX53535

Goat anti-CBARA1 (aa113-126) middle region Antibody (OAEB02772) - OAEB02772 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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