MICU1

Gene Symbol MICU1
Entrez Gene 10367
Alt Symbol CALC, CBARA1, EFHA3, MPXPS
Species Human
Gene Type protein-coding
Description mitochondrial calcium uptake 1
Other Description ara CALC|atopy-related autoantigen CALC|calcium uptake protein 1, mitochondrial|calcium-binding atopy-related autoantigen 1
Swissprots B4DPI1 A8MV96 Q9UFX0 O75785 B5MBY3 B4DJH9 Q9H9N6 Q9BPX6 D3YTJ3 B3KN20
Accessions EAW54457 EAW54458 EAW54459 Q9BPX6 AK022697 BAB14187 AK023318 BAG51182 AK225298 AK225695 AK296086 BAG58841 AK298347 BAG60593 AL117423 CAB55915 BC004190 AAH04190 BC004216 AAH04216 BC016641 AAH16641 BU627477 DB030067 DQ891087 ABM82013 EU176543 ABW03344 Y17711 CAA76830 XM_005269383 XP_005269440 XM_005269384 XP_005269441 XM_005269386 XP_005269443 XM_011539119 XP_011537421 XR_945585 XR_945586 NM_001195518 NP_001182447 NM_001195519 NP_001182448 NM_006077 NP_006068
Function Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes at the outer surface of the mitochondrion inner membrane.
Tissue Specificity Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:9806765}.

CBARA1 CRISPR/Cas9 KO Plasmid (h) - sc-418304 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 HDR Plasmid (h) - sc-418304-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 Double Nickase Plasmid (h) - sc-418304-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 Double Nickase Plasmid (h2) - sc-418304-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 CRISPR Activation Plasmid (h) - sc-418304-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 CRISPR Activation Plasmid (h2) - sc-418304-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 Lentiviral Activation Particles (h) - sc-418304-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 Lentiviral Activation Particles (h2) - sc-418304-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CBARA1 siRNA (h) - sc-90788 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CBARA1 shRNA Plasmid (h) - sc-90788-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CBARA1 shRNA (h) Lentiviral Particles - sc-90788-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CBARA1 RNAi - H00010367-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU082531 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN5405 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5405 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06468 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06468

MICU1 siRNA (Human) - CRH7024 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Micu1 (NM_006077.3) - SHH341903 from Creative biogene

Category siRNA
Species Reactivities Human

MICU1 shRNA Plasmid (Human) - CHH7024 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MICU1 miRNA 3'UTR clone - MiUTR3H-07359 from Creative biogene

Species Reactivities Human
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