MICU1

Gene Symbol MICU1
Entrez Gene 10367
Alt Symbol CALC, CBARA1, EFHA3, MPXPS
Species Human
Gene Type protein-coding
Description mitochondrial calcium uptake 1
Other Description ara CALC|atopy-related autoantigen CALC|calcium uptake protein 1, mitochondrial|calcium-binding atopy-related autoantigen 1
Swissprots B4DPI1 A8MV96 Q9UFX0 O75785 B5MBY3 B4DJH9 Q9H9N6 Q9BPX6 D3YTJ3 B3KN20
Accessions EAW54457 EAW54458 EAW54459 Q9BPX6 AK022697 BAB14187 AK023318 BAG51182 AK225298 AK225695 AK296086 BAG58841 AK298347 BAG60593 AL117423 CAB55915 BC004190 AAH04190 BC004216 AAH04216 BC016641 AAH16641 BU627477 DB030067 DQ891087 ABM82013 EU176543 ABW03344 Y17711 CAA76830 XM_005269383 XP_005269440 XM_005269384 XP_005269441 XM_005269386 XP_005269443 XM_011539119 XP_011537421 XR_945585 XR_945586 NM_001195518 NP_001182447 NM_001195519 NP_001182448 NM_006077 NP_006068
Function Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes at the outer surface of the mitochondrion inner membrane.
Tissue Specificity Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:9806765}.

Human CBARA1 full length protein - ab153073 from Abcam

Category Protein
Prices $402.00
Sizes 2 µg
Source Wheat germ
Species Human
ab153073 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CBARA1 peptide - ab126461 from Abcam

Category Peptide
Prices $176.00
Sizes 100 µg
Species Human

Human CBARA1 protein fragment - ab153074 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab153074 on a 12.5% SDS-PAGE stained with Coomassie Blue.

MICU1 / CBARA1 Antibody Blocking Peptide - LS-E27660 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

MICU1 / CBARA1 Antibody Blocking Peptide - LS-E10260 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CBARA1 Protein - H00010367-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CBAA1-Antibody-N-term-Blocking-Peptide - BP9682a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CBARA1 Peptide - AC21-2478-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

CBARA1 - H00010367-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

CBARA1 - H00010367-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CBARA1 - H00010367-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CBARA1 Peptide - 42-843P from ProSci

Category Peptide
Species Human

CBARA1 fusion protein - ag6075 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

CBARA1 - TP300921 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human

CBARA1 (full length, N-term HIS tag, transcript variant 1) - TP760929 from Acris Antibodies

Category Protein
Prices $199.00
Sizes 50 µg
Source E. coli
Species Human
CBARA1

CBARA1, Peptide - MBS427582 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat, Dog, Pig, Bovine

CBARA1 Recombinant Protein Antigen - NBP1-86663PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MICU1 Peptide, Human - M34GP09511H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CBARA1 Recombinant Protein Antigen - NBP2-58173PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E. coli
Species Human
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