| Gene Symbol |
CYP26A1
|
| Entrez Gene |
1592
|
| Alt Symbol |
CP26, CYP26, P450RAI, P450RAI1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 26, subfamily A, polypeptide 1
|
| Other Description |
P450, retinoic acid-inactivating, 1|cytochrome P450 26A1|cytochrome P450 retinoic acid-inactivating 1|cytochrome P450, subfamily XXVIA, polypeptide 1|cytochrome P450RAI|hP450RAI|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome
|
| Swissprots |
Q5VXH9 O43174 Q5VXI0 B3KNI4
|
| Accessions |
EAW50078 EAW50079 O43174 AF005418 AAB88881 AK027560 BAG51346 AK075374 BC156283 AAI56284 BC157063 AAI57064 NM_000783 NP_000774 NM_057157 NP_476498
|
| Function |
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. {ECO:0000269|PubMed:9826557}.
|
| Top Pathways |
Retinol metabolism
|