Gene Symbol | CYP26A1 |
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Entrez Gene | 1592 |
Alt Symbol | CP26, CYP26, P450RAI, P450RAI1 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 26, subfamily A, polypeptide 1 |
Other Description | P450, retinoic acid-inactivating, 1|cytochrome P450 26A1|cytochrome P450 retinoic acid-inactivating 1|cytochrome P450, subfamily XXVIA, polypeptide 1|cytochrome P450RAI|hP450RAI|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome |
Swissprots | Q5VXH9 O43174 Q5VXI0 B3KNI4 |
Accessions | EAW50078 EAW50079 O43174 AF005418 AAB88881 AK027560 BAG51346 AK075374 BC156283 AAI56284 BC157063 AAI57064 NM_000783 NP_000774 NM_057157 NP_476498 |
Function | Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. {ECO:0000269|PubMed:9826557}. |
Top Pathways | Retinol metabolism |
CYP26 / CYP26A1 Antibody Blocking Peptide - LS-E7075 from LifeSpan Bioscience
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CYP26 / CYP26A1 Antibody Blocking Peptide - LS-E26927 from LifeSpan Bioscience
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CYP26A1 Peptide - P1245 from Novus Biologicals
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CYP26A1-Antibody-Center-Blocking-Peptide - BP2754c from Abgent, a WuXi AppTec company
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Cytochrome P450 26A1 Blocking Peptide - abx062521 from Abbexa
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Recombinant Cytochrome P450 26A1 (CYP26A1) - RPD540Hu01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 26A1 (CYP26A1) - RPD540Mu01 from Uscn Life Science Inc.
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Cytochrome P450 26A1 Blocking Peptide - CBP1327 from Cohesion Biosciences
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CYP26A1 (H277) Peptide - BS2191P from Bioworld Technology
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Recombinant Cytochrome P450 26A1 (CYP26A1) - RPD540Hu01 from Cloud-clone
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Recombinant Human Cytochrome P450 26A1(CYP26A1) - CSB-YP006402HU CSB-EP006402HU CSB-BP006402HU CSB-MP006402HU from Cusabio
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Cytochrome P450 26A1 Protein (Recombinant) - abx166987 from Abbexa
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CYP26A1 (transcript variant 1) - TP316278 from Acris Antibodies
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CYP26A1-Antibody-C-term-Blocking-Peptide - BP2754d from Abgent, a WuXi AppTec company
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CYP26A1 Peptide, Human - M34GP03946H from Creative Peptides
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Recombinant Cytochrome P450 26A1 (CYP26A1) - RPU53137 from Biomatik
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CYP26A1 Recombinant Protein (OPCD02609) - OPCD02609 from Aviva Systems Biology
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Cytochrome P450 26A1, Recombinant Protein - MBS2029978 from MyBioSource
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Cytochrome P450 26A1 (CYP26A1), Recombinant Protein - MBS1060354 from MyBioSource
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CYP26A1 peptide - orb217190 from Biorbyt
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