| Gene Symbol | PLEC |
|---|---|
| Entrez Gene | 5339 |
| Alt Symbol | EBS1, EBSO, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN |
| Species | Human |
| Gene Type | protein-coding |
| Description | plectin |
| Other Description | hemidesmosomal protein 1|plectin 1, intermediate filament binding protein 500kDa |
| Swissprots | Q6S381 Q15149 Q6S377 Q6S376 Q6S380 Q15148 Q6S382 Q6S383 Q16640 Q6S378 Q6S379 |
| Accessions | AAB05428 CAA91196 CAP07515 CAP11483 CAR97097 CAT82346 EAW82170 EAW82171 EAW82172 EAW82173 EAW82174 Q15149 AF330791 AAL37482 AF330792 AAL37483 AY480044 AAR95677 AY480045 AAR95678 AY480046 AAR95679 AY480047 AAR95680 AY480048 AAR95681 AY480049 AAR95682 AY480050 AAR95683 AY480051 AAR95684 BC007597 AAH07597 BC013206 BM681271 BP231761 BP312608 BP315878 BP321327 BP359323 U53204 AAB05427 X97053 CAA65765 Z36817 XM_005250976 XP_005251033 XM_005250978 XP_005251035 XM_005250979 XP_005251036 XM_005250980 XP_005251037 XM_005250981 XP_005251038 XM_005250982 XP_005251039 XM_005250983 XP_005251040 XM_005250984 XP_005251041 XM_006716588 XP_006716651 XM_006716589 XP_006716652 XM_006716590 XP_006716653 XM_011517130 XP_011515432 XM_011517131 XP_011515433 XM_011517132 XP_011515434 NM_000445 NP_000436 NM_201378 NP_958780 NM_201379 NP_958781 NM_201380 NP_958782 NM_201381 NP_958783 NM_201382 NP_958784 NM_201383 NP_958785 NM_201384 NP_958786 |
| Function | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12482924}. Cell junction, hemidesmosome {ECO:0000269|PubMed:12482924}. |
| Tissue Specificity | Widely expressed with highest levels in muscle, heart, placenta and spinal cord. |
Human PLEC cDNA clone(NM_201379.1) - CDFG013190 from Creative Biomart
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Human PLEC cDNA clone(NM_201381.1) - CDFG013191 from Creative Biomart
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Human PLEC cDNA clone(NM_201383.1) - CDFG013193 from Creative Biomart
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Human PLEC cDNA clone(NM_201384.1) - CDFG013194 from Creative Biomart
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Human PLEC cDNA clone(NM_201380.2) - CDFG013195 from Creative Biomart
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Human PLEC ORF Clone(NM_201378.2) - CDCR326930 from Creative Biomart
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Human PLEC ORF Clone(NM_201378.2) - CDCR326931 from Creative Biomart
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Human PLEC ORF Clone(NM_201379.1) - CDCR326932 from Creative Biomart
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Human PLEC ORF Clone(NM_201379.1) - CDCR326933 from Creative Biomart
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Human PLEC ORF Clone(NM_201380.2) - CDCR326934 from Creative Biomart
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Human PLEC ORF Clone(NM_201380.2) - CDCR326935 from Creative Biomart
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Human PLEC ORF Clone(NM_201381.1) - CDCR326937 from Creative Biomart
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Human PLEC ORF Clone(NM_201382.2) - CDCR326938 from Creative Biomart
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Human PLEC ORF Clone(NM_201382.2) - CDCR326939 from Creative Biomart
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Human PLEC ORF Clone(NM_201383.1) - CDCR326940 from Creative Biomart
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Human PLEC ORF Clone(NM_201383.1) - CDCR326941 from Creative Biomart
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Human PLEC ORF Clone(NM_201384.1) - CDCR326942 from Creative Biomart
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Human PLEC ORF Clone(NM_201384.1) - CDCR326943 from Creative Biomart
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Human PLEC ORF Clone(NM_201381.1) - CDCR327020 from Creative Biomart
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Human PLEC ORF Clone(NM_000445.3) - CDCR336416 from Creative Biomart
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Human PLEC ORF Clone(NM_000445.3) - CDCR336419 from Creative Biomart
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Human PLEC ORF Clone(NM_201378.2) - CDCR326930 from Creative biogene
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Human PLEC ORF Clone(NM_201379.1) - CDCR326932 from Creative biogene
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Human PLEC ORF Clone(NM_201380.2) - CDCR326934 from Creative biogene
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Human PLEC ORF Clone(NM_201381.1) - CDCR326937 from Creative biogene
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