PLEC

Gene Symbol PLEC
Entrez Gene 5339
Alt Symbol EBS1, EBSO, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN
Species Human
Gene Type protein-coding
Description plectin
Other Description hemidesmosomal protein 1|plectin 1, intermediate filament binding protein 500kDa
Swissprots Q6S381 Q15149 Q6S377 Q6S376 Q6S380 Q15148 Q6S382 Q6S383 Q16640 Q6S378 Q6S379
Accessions AAB05428 CAA91196 CAP07515 CAP11483 CAR97097 CAT82346 EAW82170 EAW82171 EAW82172 EAW82173 EAW82174 Q15149 AF330791 AAL37482 AF330792 AAL37483 AY480044 AAR95677 AY480045 AAR95678 AY480046 AAR95679 AY480047 AAR95680 AY480048 AAR95681 AY480049 AAR95682 AY480050 AAR95683 AY480051 AAR95684 BC007597 AAH07597 BC013206 BM681271 BP231761 BP312608 BP315878 BP321327 BP359323 U53204 AAB05427 X97053 CAA65765 Z36817 XM_005250976 XP_005251033 XM_005250978 XP_005251035 XM_005250979 XP_005251036 XM_005250980 XP_005251037 XM_005250981 XP_005251038 XM_005250982 XP_005251039 XM_005250983 XP_005251040 XM_005250984 XP_005251041 XM_006716588 XP_006716651 XM_006716589 XP_006716652 XM_006716590 XP_006716653 XM_011517130 XP_011515432 XM_011517131 XP_011515433 XM_011517132 XP_011515434 NM_000445 NP_000436 NM_201378 NP_958780 NM_201379 NP_958781 NM_201380 NP_958782 NM_201381 NP_958783 NM_201382 NP_958784 NM_201383 NP_958785 NM_201384 NP_958786
Function Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12482924}. Cell junction, hemidesmosome {ECO:0000269|PubMed:12482924}.
Tissue Specificity Widely expressed with highest levels in muscle, heart, placenta and spinal cord.

Plectin-1 (D6A11) Rabbit mAb - 12254 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6A11
Western blot analysis of extracts from COS-7 and U-2 OS cells using Plectin-1 (D6A11) Rabbit mAb.

Plectin-1 Antibody - 2863 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using Plectin-1 Antibody. Molecular weights were determined using a pre-stained molecular weight marker (not shown).

Plectin (C-20) - sc-7572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Plectin (C-20): sc-7572. Immunofluorescence staining of methanol-fixed A549 cells showing cytoskeletal localization.

Plectin (H-80) - sc-28267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Plectin (H-80): sc-28267. Immunofluorescence staining of normal mouse intestine frozen section showing cytoskeletal staining.

Plectin (10F6) - sc-33649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Plectin (10F6): sc-33649. Western blot analysis of Plectin expression in rat brain tissue extract.

Anti-Plectin antibody - ab83497 from Abcam

Prices $381.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Plectin antibody (ab83497) at 1/500 dilutionLane 1 : Mouse brain tissue lysateLane 2 : Rat brain tissue lysate

Anti-Plectin antibody [7A8] - ab11220 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A8
ab11220 staining Plectin (red) in Rat tibialis anterior muscle tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with 3% paraformaldehyde, 0.1% phosphate buffer, pH 7.4 for 1 hour at 4°C, cyroprotected with 0.7M sucrose, and frozen in liquid nitrogen-cooled isopentane. Cryostat 10µm-thick sections were incubated with primary antibody (2-5µg/ml). Top - plectin staining, Bottom - Merge of Ankyrins-G (green) and plectin (red) staining. Bar, 20µm.

Anti-Plectin antibody [E398P] - ab32528 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E398P
Immunohistochemical staining of paraffin-embedded human skeletal muscle using ab32528 at a dilution of 1/250

Anti-Plectin antibody - C-terminal - ab192706 from Abcam

Prices $372.00
Sizes 50 µl
Clonality Polyclonal

Anti-PLEC / Plectin Antibody (aa4367-4684) - LS-C38257 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Guinea Pig
Clonality Polyclonal

Anti-PLEC / Plectin Antibody (aa4367-4684) - LS-C38258 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Guinea Pig
Clonality Polyclonal

Anti-PLEC / Plectin Antibody - LS-C38259 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PLEC / Plectin Antibody (aa4367-4684) - LS-C86201 from LifeSpan Bioscience

Prices $695.00
Sizes 100 µl
Host Guinea Pig
Clonality Polyclonal

Anti-PLEC / Plectin Antibody (Biotin) - LS-C38260 from LifeSpan Bioscience

Prices $560.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-PLEC / Plectin Antibody - LS-C124382 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PLEC / Plectin Antibody (clone 10F6) - LS-C58284 from LifeSpan Bioscience

Prices $390.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 10F6

Anti-PLEC / Plectin Antibody (Internal) - LS-C91933 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PLEC / Plectin Antibody (C-Terminus) - LS-C193727 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Guinea Pig
Clonality Polyclonal

Anti-PLEC / Plectin Antibody (clone 4D12) - LS-C197921 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D12
Detection limit for recombinant GST tagged PLEC1 is approximately 0.3 ng/ml as a capture antibody.

Anti-PLEC / Plectin Antibody (C-Terminus, clone E398P) IHC-plus™ - LS-B8172 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone E398P
Anti-Plectin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8172 dilution 1:50.

Plectin Antibody (7A8) - NB120-11220 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A8

Plectin Antibody - NBP1-84019 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Plectin Antibody [NBP1-84019] - Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol, intermediate filaments & focal adhesion sites.

PLEC1 Antibody - NBP1-92276 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PLEC1 Antibody [NBP1-92276] - Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

PLEC1 Antibody - NBP1-92275 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PLEC1 Antibody [NBP1-92275] - Staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells.

Plectin Antibody (4D12) - H00005339-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D12
Sandwich ELISA: Plectin Antibody (4D12) [H00005339-M02] - Detection limit for recombinant GST tagged PLEC1 is approximately 0.3ng/ml as a capture antibody.
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