KITLG

Gene Symbol	KITLG
Entrez Gene	4254
Alt Symbol	FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7
Species	Human
Gene Type	protein-coding
Description	KIT ligand
Other Description	c-Kit ligand|familial progressive hyperpigmentation 2|kit ligand|mast cell growth factor|steel factor|stem cell factor
Swissprots	Q7M4N8 Q9UQK7 Q68DZ2 A8K2Q4 B7ZLM4 A0AV09 P21583 Q16487
Accessions	AAB39247 EAW97416 EAW97417 EAW97418 EAW97419 P21583 AF119835 AAD22048 AF400436 AAK92485 AF400437 AAK92486 AK025245 AK055903 AK290319 BAF83008 AK293002 BAF85691 BC069733 AAH69733 BC069783 AAH69783 BC069797 AAH69797 BC074725 AAH74725 BC126166 AAI26167 BC143899 AAI43900 BX474960 CR749222 CAH18078 DC320486 HQ447471 ADQ31957 M59964 AAA85450 S42571 AAB22846 S45983 AAB23572 S45995 AAB23573 S80491 AAB35922 NM_000899 NP_000890 NM_003994 NP_003985
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location	Soluble KIT ligand: Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SCF Human ELISA Kit - ab100636 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 2 pg/ml Range 2.74 pg/ml - 2000 pg/ml

Stem Cell Factor (Kit Ligand) Human ELISA Kit - ab108901 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 0.15 ng/ml Range 0.156 ng/ml - 40 ng/ml

Human KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5176 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 5.6 pg/ml Range 2.743-666.7 pg/ml

Rat KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5178 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 6.3 pg/ml Range 2.743-666.7 pg/ml

Mouse KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5177 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Sensitivity 6.2 pg/ml Range 2.743-666.7 pg/ml

Bovine KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5989 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 5.7 pg/ml Range 2.743-666.7 pg/ml

Pig KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5991 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 2.9 pg/ml Range 2.743-666.7 pg/ml

Dog KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F5990 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 6.5 pg/ml Range 2.743-666.7 pg/ml

Mouse KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F2546 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Mouse KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F288 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.743 pg/ml Range 2.743-666.7 pg/ml

Human KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F597 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.743-666.7 pg/ml

Human KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F182 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.743 pg/ml Range 2.743-666.7 pg/ml

Dog/Canine KITLG / SCF ELISA Kit (Custom ELISA) - LS-F325 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 2.743-666.7 pg/ml

Rat KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F631 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.743-666.7 pg/ml

Mouse KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F623 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.743-666.7 pg/ml

Human KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F12566 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 31.2 Range 2.743-666.7 pg/ml

Rat KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F12565 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 2.743-666.7 pg/ml

Bovine KITLG / SCF ELISA Kit (Sandwich ELISA) - LS-F12567 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 78 Range 2.743-666.7 pg/ml

Human SCF ELISA Kit - RAB0330 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human SCF Biotinylated Fluorokine Flow Cytometry Kit - NFKL0 from R&D Systems Prices $465.00 Sizes 1 kit

Mouse SCF Biotinylated Fluorokine Flow Cytometry Kit - NFMKL0 from R&D Systems Prices $409.00 Sizes 1 kit

Human SCF Quantikine ELISA Kit - DCK00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 9 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)

Mouse SCF Quantikine ELISA Kit - MCK00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 5 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)

Mouse SCF DuoSet ELISA - DY455 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human SCF DuoSet ELISA - DY255 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

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