| Gene Symbol | KITLG |
|---|---|
| Entrez Gene | 4254 |
| Alt Symbol | FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | KIT ligand |
| Other Description | c-Kit ligand|familial progressive hyperpigmentation 2|kit ligand|mast cell growth factor|steel factor|stem cell factor |
| Swissprots | Q7M4N8 Q9UQK7 Q68DZ2 A8K2Q4 B7ZLM4 A0AV09 P21583 Q16487 |
| Accessions | AAB39247 EAW97416 EAW97417 EAW97418 EAW97419 P21583 AF119835 AAD22048 AF400436 AAK92485 AF400437 AAK92486 AK025245 AK055903 AK290319 BAF83008 AK293002 BAF85691 BC069733 AAH69733 BC069783 AAH69783 BC069797 AAH69797 BC074725 AAH74725 BC126166 AAI26167 BC143899 AAI43900 BX474960 CR749222 CAH18078 DC320486 HQ447471 ADQ31957 M59964 AAA85450 S42571 AAB22846 S45983 AAB23572 S45995 AAB23573 S80491 AAB35922 NM_000899 NP_000890 NM_003994 NP_003985 |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Subcellular Location | Soluble KIT ligand: Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway |