KITLG

Gene Symbol KITLG
Entrez Gene 4254
Alt Symbol FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7
Species Human
Gene Type protein-coding
Description KIT ligand
Other Description c-Kit ligand|familial progressive hyperpigmentation 2|kit ligand|mast cell growth factor|steel factor|stem cell factor
Swissprots Q7M4N8 Q9UQK7 Q68DZ2 A8K2Q4 B7ZLM4 A0AV09 P21583 Q16487
Accessions AAB39247 EAW97416 EAW97417 EAW97418 EAW97419 P21583 AF119835 AAD22048 AF400436 AAK92485 AF400437 AAK92486 AK025245 AK055903 AK290319 BAF83008 AK293002 BAF85691 BC069733 AAH69733 BC069783 AAH69783 BC069797 AAH69797 BC074725 AAH74725 BC126166 AAI26167 BC143899 AAI43900 BX474960 CR749222 CAH18078 DC320486 HQ447471 ADQ31957 M59964 AAA85450 S42571 AAB22846 S45983 AAB23572 S45995 AAB23573 S80491 AAB35922 NM_000899 NP_000890 NM_003994 NP_003985
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location Soluble KIT ligand: Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway

SCF (C19H6) Rabbit mAb - 2093 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C19H6
Western blot analysis of recombinant SCF (5 ng) using SCF (C19H6) Rabbit mAb.

SCF Antibody - 2273 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant SCF #9907, using SCF Antibody.

SCF (H-189) - sc-9132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SCF (H-189): sc-9132. Western blot analysis of SCF expression in HeLa (A), SW480 (B) and A549 (C) whole cell lysates.

SCF (G-19) - sc-1303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SCF (G-19): sc-1303. Western blot analysis of truncated human recombinant SCF protein.

SCF (G-3) - sc-13126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SCF (G-3): sc-13126. Western blot analysis of human recombinant SCF.

SCF (N-19) - sc-1302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SCF (N-19): sc-1302. Western blot analysis of human recombinant SCF protein.

Anti-SCF antibody - ab9716 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9716 staining SCF in human pancreatic adenocarcinoma tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent proteinase K mediated antigen retrieval at room temperature. The primary antibody was used at 0.5 ug/ml and incubated with sample at 4°C overnight. A HRP-labeled polymer detection system was used with an alcohol-soluble AEC chromogen.

Anti-SCF antibody [1.2_2H5-1C10] - ab17482 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1.2_2H5-1C10

Anti-SCF antibody (Biotin) - ab84267 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SCF antibody (Biotin) - ab84444 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SCF antibody [EP665Y] - ab52603 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP665Y
Anti-SCF antibody [EP665Y] (ab52603) at 1/10000 dilution + recombinant protein (5ng)SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-SCF antibody [MM0531-13F4] - ab90235 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0531-13F4

Anti-SCF antibody - N-terminal - ab71516 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SCF antibody - N-terminal (ab71516) at 1/50 dilutionLane 1 : Nontransfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with the SCF geneLysates/proteins at 2 µg per lane.

Anti-KITLG / SCF Antibody (clone 5F6) - LS-C338420 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5F6
IHC of paraffin-embedded Human lymph node tissue using anti-KITLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-KITLG / SCF Antibody - LS-C104667 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal
IHC of SCF antibody LS-C104667

Anti-KITLG / SCF Antibody (aa180-229) IHC-plus™ - LS-B4658 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KITLG / SCF antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4658 concentration 5 ug/ml.

Anti-KITLG / SCF Antibody - LS-C48864 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KITLG / SCF Antibody - LS-C48865 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KITLG / SCF Antibody - LS-C87116 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-KITLG / SCF Antibody - LS-C87118 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-KITLG / SCF Antibody - LS-C90840 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Mouse
Clonality Monoclonal

Anti-KITLG / SCF Antibody (clone hKL12) - LS-C96331 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone hKL12

Anti-KITLG / SCF Antibody - LS-C104578 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 50 µg, 100 µg
Host Goat
Clonality Polyclonal

Anti-KITLG / SCF Antibody (Biotin) - LS-C104577 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Goat
Clonality Polyclonal

Anti-KITLG / SCF Antibody (Biotin) - LS-C104803 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Goat
Clonality Polyclonal
Search more