| Gene Symbol |
ITPR2
|
| Entrez Gene |
3709
|
| Alt Symbol |
ANHD, CFAP48, IP3R2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inositol 1,4,5-trisphosphate receptor, type 2
|
| Other Description |
IP3 receptor|IP3R 2|cilia and flagella associated protein 48|inositol 1,4,5-triphosphate receptor, type 2|inositol 1,4,5-trisphosphate receptor type 2|insP3R2|type 2 InsP3 receptor|type 2 inositol 1,4,5-trisphosphate receptor
|
| Swissprots |
Q14571 O94773
|
| Accessions |
AFI41831 EAW96534 EAW96535 Q14571 AB012610 BAA33961 AI339141 AK307686 AK307712 AK310504 AL711179 AY429550 BC172383 AAI72383 BE439696 BP314401 BP364657 BU173910 BX495410 CA419735 D26350 BAA05384 DB144849 XM_011520645 XP_011518947 XM_011520646 XP_011518948 XR_931288 NM_002223 NP_002214
|
| Function |
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform Short is found in skeletal muscle and heart.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Estrogen signaling pathway
|