P2RY12
| Gene Symbol | P2RY12 |
|---|---|
| Entrez Gene | 64805 |
| Alt Symbol | ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999 |
| Species | Human |
| Gene Type | protein-coding |
| Description | purinergic receptor P2Y, G-protein coupled, 12 |
| Other Description | ADP-glucose receptor|G-protein coupled receptor SP1999|Gi-coupled ADP receptor HORK3|P2Y purinoceptor 12|P2Y12 platelet ADP receptor|purinergic receptor P2RY12|putative G-protein coupled receptor |
| Swissprots | D3DNJ5 Q546J7 Q9H244 |
| Accessions | AAL32292 BAB89309 EAW78803 EAW78804 Q9H244 AA810452 AB052684 BAB60824 AF313449 AAG48944 AF321815 AAK00948 AJ320495 CAC87144 AK292096 BAF84785 AK303714 BAG64695 AK316575 BAG38164 AW015793 AW976204 AY136754 AAN01280 BC017898 AAH17898 BM926255 DA179496 DA267276 DA343254 DB306976 DC313627 DQ893186 ABM84112 DQ896506 ABM87505 NM_022788 NP_073625 NM_176876 NP_795345 |
| Function | Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}; Multi-pass membrane protein {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}. |
| Tissue Specificity | Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873}. |
P2Y12 CRISPR/Cas9 KO Plasmid (h) - sc-417999 from Santa Cruz Biotechnology
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P2Y12 HDR Plasmid (h) - sc-417999-HDR from Santa Cruz Biotechnology
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P2Y12 Double Nickase Plasmid (h) - sc-417999-NIC from Santa Cruz Biotechnology
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P2Y12 Double Nickase Plasmid (h2) - sc-417999-NIC-2 from Santa Cruz Biotechnology
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P2Y12 CRISPR Activation Plasmid (h) - sc-417999-ACT from Santa Cruz Biotechnology
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P2Y12 CRISPR Activation Plasmid (h2) - sc-417999-ACT-2 from Santa Cruz Biotechnology
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P2Y12 Lentiviral Activation Particles (h) - sc-417999-LAC from Santa Cruz Biotechnology
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P2Y12 Lentiviral Activation Particles (h2) - sc-417999-LAC-2 from Santa Cruz Biotechnology
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P2Y12 siRNA (h) - sc-106340 from Santa Cruz Biotechnology
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P2Y12 shRNA Plasmid (h) - sc-106340-SH from Santa Cruz Biotechnology
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P2Y12 shRNA (h) Lentiviral Particles - sc-106340-V from Santa Cruz Biotechnology
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P2Y12/P2RY12 RNAi - H00064805-R03 from Novus Biologicals
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P2Y12/P2RY12 RNAi - H00064805-R04 from Novus Biologicals
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MISSION® esiRNA - EHU039261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16233 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16233 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01360 from Sigma-Aldrich
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P2RY12 siRNA (Human) - CRJ2104 from Cohesion Biosciences
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shRNA set against Human P2RY12 (NM_022788.3) - SHH369552 from Creative biogene
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shRNA set against Human P2RY12(NM_022788.3) - SHR085350 from Creative biogene
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shRNA set against Human P2RY12(NM_176876.1) - SHR085404 from Creative biogene
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P2RY12 shRNA Plasmid (Human) - CHJ2104 from Cohesion Biosciences
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P2RY12 miRNA 3'UTR clone - MiUTR1H-07443 from Creative biogene
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P2RY12 miRNA 3'UTR clone - MiUTR1H-07444 from Creative biogene
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