P2RY12

Gene Symbol P2RY12
Entrez Gene 64805
Alt Symbol ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
Species Human
Gene Type protein-coding
Description purinergic receptor P2Y, G-protein coupled, 12
Other Description ADP-glucose receptor|G-protein coupled receptor SP1999|Gi-coupled ADP receptor HORK3|P2Y purinoceptor 12|P2Y12 platelet ADP receptor|purinergic receptor P2RY12|putative G-protein coupled receptor
Swissprots D3DNJ5 Q546J7 Q9H244
Accessions AAL32292 BAB89309 EAW78803 EAW78804 Q9H244 AA810452 AB052684 BAB60824 AF313449 AAG48944 AF321815 AAK00948 AJ320495 CAC87144 AK292096 BAF84785 AK303714 BAG64695 AK316575 BAG38164 AW015793 AW976204 AY136754 AAN01280 BC017898 AAH17898 BM926255 DA179496 DA267276 DA343254 DB306976 DC313627 DQ893186 ABM84112 DQ896506 ABM87505 NM_022788 NP_073625 NM_176876 NP_795345
Function Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}; Multi-pass membrane protein {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}.
Tissue Specificity Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873}.

P2Y12 (P-14) - sc-27152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P2Y12 (P-14): sc-27152. Western blot analysis of P2Y12 expression in non-transfected: sc-117752 (A) and mouse P2Y12 transfected: sc-122313 (B) 293T whole cell lysates.

Anti-P2Y12 antibody - ab183066 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling P2Y12 with ab183066 at 1/25 dilution, in the presence (right image) or absence (left image) of immunizing peptide. 

Anti-P2Y12 antibody - ab86195 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab86195 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab86195 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-P2Y12 antibody - N-terminal - ab140862 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human blood platelet tissue labelling P2Y12 with ab140862 at 32 µg/ml.

Anti-P2RY12 / P2Y12 Antibody (Extracellular Domain) IHC-plus™ - LS-A3745 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-P2RY12 / P2Y12 antibody LS-A3745 IHC of human bone marrow, megakaryocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-P2RY12 / P2Y12 Antibody (N-Terminus) IHC-plus™ - LS-A3742 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-P2RY12 / P2Y12 antibody LS-A3742 IHC of human blood, platelets. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-P2RY12 / P2Y12 Antibody - LS-C182376 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-P2RY12 / P2Y12 Antibody - LS-C189147 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-P2RY12 / P2Y12 Antibody (aa324-342) - LS-C209713 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-P2RY12 / P2Y12 Antibody - LS-C209714 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

P2Y12/P2RY12 Antibody - NBP2-33870 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP2-33870] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in microglia.

P2Y12/P2RY12 Antibody - NBP1-89673 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: P2Y12 Antibody [NBP1-89673] - Staining of human lymph node shows strong cytoplasmic positivity in reaction center cells, lymphoid cells outside reaction centra.

P2Y1/P2RY1 Antibody - NBP1-69246 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: P2Y1/P2RY1 Antibody [NBP1-69246]

P2Y12/P2RY12 Antibody - NLS3742 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry: P2Y12/P2RY12 Antibody [NLS3742] - Analysis of anti-P2RY12 / P2Y12 antibody with HEK293 human embryonic kidney cells

P2Y12/P2RY12 Antibody - NBP1-78249 from Novus Biologicals

Prices $449.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: P2Y12/P2RY12 Antibody [NBP1-78249] - Antibody dilution 1:500, MW is 41 kDa

P2Y12/P2RY12 Antibody - NBP1-30745 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

P2Y12/P2RY12 Antibody - NBP2-19660 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: P2Y12/P2RY12 Antibody [NBP2-19660] - Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG D: SK-N-SH 10% SDS PAGE gel, diluted at 1:1000.

P2Y12 Polyclonal Antibody - bs-12072R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat anterior horn of spinal cord labeled with Anti-P2Y12 Polyclonal Antibody, Unconjugated (bs-12072R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Rabbit Anti-P2Y12 Polyclonal Antibody, Cy3 Conjugated - bs-12072R-Cy3 from Bioss

Host Rabbit
Clonality Polyclonal

Rabbit Anti-P2Y12 Polyclonal Antibody, Cy5 Conjugated - bs-12072R-Cy5 from Bioss

Host Rabbit
Clonality Polyclonal
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