| Gene Symbol |
PERP
|
| Entrez Gene |
64065
|
| Alt Symbol |
KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PERP, TP53 apoptosis effector
|
| Other Description |
1110017A08Rik|KCP-1|keratinocyte associated protein 1|keratinocyte-associated protein 1|keratinocytes associated protein 1|p53 apoptosis effector related to PMP-22|p53 apoptosis effector related to PMP22|p53-induced protein PIGPC1|transmembrane protein THW
|
| Swissprots |
Q9H230 Q8NC16 Q8N1J6 Q9H1C5 Q8IWS3 B2RB73 E1P590 Q96FX8
|
| Accessions |
CAF85829 CCF76964 EAW47920 EAW47921 Q96FX8 AF317550 AAG35063 AJ251830 CAC17766 AK074585 BAC11074 AK075082 BAC11390 AK093516 BAG52734 AK097387 BAG53462 AK097958 BAC05205 AK225907 AK314526 BAG37120 AY157578 AAO13162 BC010163 AAH10163 BU674771 CA310443 CX784592 DA750046 DQ892670 ABM83596 DR422553 EU176724 ABW03525 NM_022121 NP_071404
|
| Function |
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, desmosome. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Associated with desmosomes. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. {ECO:0000269|PubMed:12752121}.
|
| Top Pathways |
p53 signaling pathway
|
