Gene Symbol | INHBC |
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Entrez Gene | 3626 |
Alt Symbol | IHBC |
Species | Human |
Gene Type | protein-coding |
Description | inhibin, beta C |
Other Description | activin beta-C chain|inhibin beta C chain |
Swissprots | A1L3Y2 P55103 |
Accessions | EAW97011 P55103 AK314849 BAG37366 BC020693 BC130324 AAI30325 BC130326 AAI30327 BP237373 BX105206 NM_005538 NP_005529 |
Function | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in benign prostatic hyperplasia. {ECO:0000269|PubMed:9428386}. |
Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Inhibin β-C siRNA (h) - sc-39787 from Santa Cruz Biotechnology
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Inhibin β-C shRNA Plasmid (h) - sc-39787-SH from Santa Cruz Biotechnology
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Inhibin β-C shRNA (h) Lentiviral Particles - sc-39787-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10679 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10679 from Sigma-Aldrich
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INHBC siRNA (Human) - CRH2430 from Cohesion Biosciences
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INHBC - MBS8222782 from MyBioSource
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shRNA set against Human INHBC (NM_005538.2) - SHH319565 from Creative biogene
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shRNA set against Human INHBC(NM_005538.2) - SHL178010 from Creative biogene
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INHBC shRNA Plasmid (Human) - CHH2430 from Cohesion Biosciences
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INHBC miRNA 3'UTR clone - MiUTR1H-04950 from Creative biogene
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