POLQ

Gene Symbol POLQ
Entrez Gene 10721
Alt Symbol POLH, PRO0327
Species Human
Gene Type protein-coding
Description polymerase (DNA directed), theta
Other Description DNA polymerase eta|DNA polymerase theta
Swissprots Q6VMB5 O75417 O95160
Accessions EAW79510 EAW79511 EAW79512 EAW79513 EAW79514 O75417 AA767021 AB209867 BAD93104 AF043628 AAD05272 AF052573 AAC33565 AF090919 AAF24036 AW021928 AY032677 AAK39635 AY338826 AAR08421 BC034254 BC172289 AAI72289 BP365212 CR936627 CAI56770 XM_011512343 XP_011510645 XM_011512344 XP_011510646 XM_011512345 XP_011510647 XM_011512346 XP_011510648 XM_011512347 XP_011510649 XM_011512348 XP_011510650 XM_011512349 XP_011510651 XM_011512350 XP_011510652 XM_011512351 XP_011510653 XM_011512352 XP_011510654 XM_011512353 XP_011510655 XM_011512354 XP_011510656 XR_924091 XR_924092 XR_924093 NM_199420 NP_955452
Function DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-
Subcellular Location Nucleus {ECO:0000250|UniProtKB:O18475}. Chromosome {ECO:0000269|PubMed:25642963}. Note=Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122). {ECO:0000269|PubMed:24989122, ECO:0000269|PubMed:25642963}.
Tissue Specificity Highly expressed in testis. {ECO:0000269|PubMed:14576298}.

human POLQ ORF clone (NM_199420.3) - CDCH065813 from Creative biogene

Species Human
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