POLQ

Gene Symbol	POLQ
Entrez Gene	10721
Alt Symbol	POLH, PRO0327
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), theta
Other Description	DNA polymerase eta|DNA polymerase theta
Swissprots	Q6VMB5 O75417 O95160
Accessions	EAW79510 EAW79511 EAW79512 EAW79513 EAW79514 O75417 AA767021 AB209867 BAD93104 AF043628 AAD05272 AF052573 AAC33565 AF090919 AAF24036 AW021928 AY032677 AAK39635 AY338826 AAR08421 BC034254 BC172289 AAI72289 BP365212 CR936627 CAI56770 XM_011512343 XP_011510645 XM_011512344 XP_011510646 XM_011512345 XP_011510647 XM_011512346 XP_011510648 XM_011512347 XP_011510649 XM_011512348 XP_011510650 XM_011512349 XP_011510651 XM_011512350 XP_011510652 XM_011512351 XP_011510653 XM_011512352 XP_011510654 XM_011512353 XP_011510655 XM_011512354 XP_011510656 XR_924091 XR_924092 XR_924093 NM_199420 NP_955452
Function	DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:O18475}. Chromosome {ECO:0000269|PubMed:25642963}. Note=Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122). {ECO:0000269|PubMed:24989122, ECO:0000269|PubMed:25642963}.
Tissue Specificity	Highly expressed in testis. {ECO:0000269|PubMed:14576298}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA pol θ (D-15) - sc-10992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DNA Polymerase theta antibody - ab80906 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNA Polymerase theta antibody - ab77151 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DNA Polymerase theta antibody - ab111218 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLQ / DNA Polymerase Theta Antibody (aa1677-1689) - LS-C112782 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-POLQ / DNA Polymerase Theta Antibody (aa181-230) - LS-C118709 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

DNA polymerase theta Antibody - NBP2-13786 from Novus Biologicals Host Rabbit Clonality Polyclonal

DNA polymerase theta Antibody (1C11) - H00010721-M09 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C11

DNA polymerase theta Antibody - NBP1-36950 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

DNA Polymerase theta/POLH Antibody - bs-13022R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, ALEXA FLUOR® 350 Conjugated - bs-13022R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, ALEXA FLUOR® 488 Conjugated - bs-13022R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, ALEXA FLUOR® 555 Conjugated - bs-13022R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, ALEXA FLUOR® 647 Conjugated - bs-13022R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, Cy3 Conjugated - bs-13022R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, Cy5 Conjugated - bs-13022R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, Cy5.5 Conjugated - bs-13022R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, Cy7 Conjugated - bs-13022R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, FITC Conjugated - bs-13022R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, Biotin Conjugated - bs-13022R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit

DNA Polymerase theta/POLH Antibody, HRP Conjugated - bs-13022R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit

Anti-POLQ antibody produced in rabbit - HPA048931 from Sigma-Aldrich Host Rabbit Clonality Polyclonal

Anti-POLQ antibody produced in rabbit - AV49203 from Sigma-Aldrich Host Rabbit Clonality Polyclonal

DNA-polymerase-theta-Antibody-internal-region - AF2748a from Abgent, a WuXi AppTec company Prices $325.00 Sizes 100 µg Host Goat Clonality Polyclonal

POLQ Antibody (OAAF02053) - OAAF02053 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Search more