| Gene Symbol |
SMYD1
|
| Entrez Gene |
150572
|
| Alt Symbol |
BOP, KMT3D, ZMYND18, ZMYND22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET and MYND domain containing 1
|
| Other Description |
CD8 beta opposite|SET and MYND domain-containing protein 1|histone-lysine N-methyltransferase SMYD1|zinc finger, MYND domain containing 18
|
| Swissprots |
A0AV30 Q8NB12 A6NE13
|
| Accessions |
EAW77077 EAW77078 EAW77079 EAW77080 Q8NB12 AF086123 AK022290 AK091724 BAC03732 AL832035 CAI46139 AY518933 AAT44535 AY518934 AAT44536 BC017915 BC126191 AAI26192 BX647878 CAI46077 EU831908 ACE87349 EU832002 ACE86665 HQ258264 ADR83018 XM_005264156 XP_005264213 NM_198274 NP_938015
|
| Function |
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expression seems mostly restricted to heart and skeletal muscle. {ECO:0000269|PubMed:19783823}.
|