| Gene Symbol |
EMP2
|
| Entrez Gene |
2013
|
| Alt Symbol |
XMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epithelial membrane protein 2
|
| Other Description |
-
|
| Swissprots |
P54851 D3DUF8 B2R7V6
|
| Accessions |
AAL27085 EAW85180 EAW85181 EAW85182 P54851 AA854747 AF190163 AAQ13707 AK096403 AK123602 AK127600 AK313134 BAG35953 AL600791 AV657588 BC009687 AAH09687 BC016019 BF981157 BF982173 BM755118 BP395690 BQ676037 BU838264 BU951297 DA646653 DA752772 HY116508 U52100 AAC51779 X94770 CAA64393 XM_006720864 XP_006720927 NM_001424 NP_001415
|
| Function |
Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250|UniProtKB:O88662}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:21637765}. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft {ECO:0000269|PubMed:21637765}. Cytoplasm {ECO:0000269|PubMed:21637765}. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane. {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}.
|
| Tissue Specificity |
Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941). {ECO:0000269|PubMed:12710941}.
|