EMP2

Gene Symbol EMP2
Entrez Gene 2013
Alt Symbol XMP
Species Human
Gene Type protein-coding
Description epithelial membrane protein 2
Other Description -
Swissprots P54851 D3DUF8 B2R7V6
Accessions AAL27085 EAW85180 EAW85181 EAW85182 P54851 AA854747 AF190163 AAQ13707 AK096403 AK123602 AK127600 AK313134 BAG35953 AL600791 AV657588 BC009687 AAH09687 BC016019 BF981157 BF982173 BM755118 BP395690 BQ676037 BU838264 BU951297 DA646653 DA752772 HY116508 U52100 AAC51779 X94770 CAA64393 XM_006720864 XP_006720927 NM_001424 NP_001415
Function Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration
Subcellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:O88662}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:21637765}. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft {ECO:0000269|PubMed:21637765}. Cytoplasm {ECO:0000269|PubMed:21637765}. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane. {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}.
Tissue Specificity Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941). {ECO:0000269|PubMed:12710941}.

EMP-2 (M-21) - sc-101949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EMP-2 (M-21): sc-101949. Western blot analysis of EMP-2 expression in Jurkat whole cell lysate.

Anti-EMP2 antibody - ab198927 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling EMP2 using ab198927 at 1/20 dilution.

Anti-EMP2 antibody - ab105514 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EMP2 antibody (ab105514) at 1.25 µg/ml + HepG2 cell lysate at 10 µg

Anti-EMP2 antibody - C-terminal - ab174699 from Abcam

Prices $407.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin-embedded Human skin (epidermis) tissue, labeling EMP2 with ab174699 at 10 µg/ml.

Anti-EMP2 Antibody (aa99-129, AP) - LS-C213782 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129, APC) - LS-C213783 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129, Biotin) - LS-C213784 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129, FITC) - LS-C213785 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129, Azide-free, HRP) - LS-C213786 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129) - LS-C321105 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa99-129, PE) - LS-C213787 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 Antibody (aa100-129) IHC-plus™ - LS-B8772 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-EMP2 antibody IHC staining of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-EMP2 Antibody (C-Terminus) - LS-C31949 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
EMP2 antibody LS-C31949 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.

EMP2 Antibody - NBP1-86847 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EMP2 Antibody [NBP1-86847] - Analysis in human cell line MCF-7.

EMP2 Antibody - NBP1-62705 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EMP2 Antibody [NBP1-62705] - analysis of EMP2 in EMP2 overexpression lysate (Cat# NBL1-10260) and recombinant protein using anti-EMP2 antibody. Image from verified customer review.

EMP2 Polyclonal Antibody - bs-6264R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EMP2 antibody produced in rabbit - AV41470 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EMP2: <B>Cat. No. AV41470</B>: Immunohistochemistry of EMP2 in Human Lung tissue with EMP2 antibody at 4-8 μg/mL.

ANTI-EMP2(C-TERMINAL) antibody produced in rabbit - SAB1307053 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-EMP2 (C-term): <B>Cat. No. SAB1307053</B>: EMP2 Antibody (C-term) western blot analysis in Mouse lung tissue lysates (35 μg/lane).

Anti-EMP2 antibody produced in rabbit - HPA014711 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EMP2: <B>Cat. No. HPA014711</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney shows strong cytoplasmic positivity in cells in glomeruli.

EMP2 antibody - middle region (ARP41470_T100) - ARP41470_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EMP2-Antibody-C-term - AP13581b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
EMP2 Antibody (C-term) (Cat. #AP13581b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the EMP2 antibody detected the EMP2 protein (arrow).

EMP2 antibody, Internal - GTX47154 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-EMP2 antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX47154

EMP2 Antibody - C-terminal region (OAAB09882) - OAAB09882 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Anti -EMP2 (Epithelial Membrane Protein 2, EMP-2, Protein XMP, XMP, MGC9056) - 137933 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

EMP2 antibody - 70R-1915 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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