EMP2

Gene Symbol EMP2
Entrez Gene 2013
Alt Symbol XMP
Species Human
Gene Type protein-coding
Description epithelial membrane protein 2
Other Description -
Swissprots P54851 D3DUF8 B2R7V6
Accessions AAL27085 EAW85180 EAW85181 EAW85182 P54851 AA854747 AF190163 AAQ13707 AK096403 AK123602 AK127600 AK313134 BAG35953 AL600791 AV657588 BC009687 AAH09687 BC016019 BF981157 BF982173 BM755118 BP395690 BQ676037 BU838264 BU951297 DA646653 DA752772 HY116508 U52100 AAC51779 X94770 CAA64393 XM_006720864 XP_006720927 NM_001424 NP_001415
Function Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration
Subcellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:O88662}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:21637765}. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft {ECO:0000269|PubMed:21637765}. Cytoplasm {ECO:0000269|PubMed:21637765}. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane. {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}.
Tissue Specificity Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941). {ECO:0000269|PubMed:12710941}.

EMP2 293 Cell Lysate - 400553 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

EMP2 Overexpression Lysate (Native) - NBL1-10260 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: EMP2 Overexpression Lysate (Native) [NBL1-10260] - analysis of EMP2 in EMP2 Overexpression Lysate using anti-EMP2 antibody (Cat.# NBP1-86847, 1:500 dilution). Image from verified customer review.

EMP2 Over-expression Lysate Product - GWB-A412C1 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human EMP2 Knockdown Stable Cell Line - CSC-DC004916 from Creative biogene

Category Cell Line
Species Human
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