| Gene Symbol | DOK1 |
|---|---|
| Entrez Gene | 1796 |
| Alt Symbol | P62DOK |
| Species | Human |
| Gene Type | protein-coding |
| Description | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
| Other Description | Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62 |
| Swissprots | Q53TY2 O43204 Q99704 Q9UHG6 |
| Accessions | AAX93224 EAW99612 EAW99613 EAW99614 Q99704 AF035299 AAB88182 AF180527 AAF19167 AK055944 BAG51595 AK127127 BAG54440 AK127656 BAG54544 AK222883 BAD96603 AK296154 BAG58893 AK300097 BAG61898 AK314678 BC111055 AAI11056 BC114440 AAI14441 BC114497 AAI14498 BQ575925 DA382785 DA599419 U70987 AAC51127 XM_011532669 XP_011530971 XM_011532670 XP_011530972 NM_001197260 NP_001184189 NM_001381 NP_001372 |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Subcellular Location | Isoform 1: Cytoplasm. Nucleus. |
| Tissue Specificity | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}. |
| Top Pathways | Measles |