DOK1

Gene Symbol	DOK1
Entrez Gene	1796
Alt Symbol	P62DOK
Species	Human
Gene Type	protein-coding
Description	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Other Description	Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62
Swissprots	Q53TY2 O43204 Q99704 Q9UHG6
Accessions	AAX93224 EAW99612 EAW99613 EAW99614 Q99704 AF035299 AAB88182 AF180527 AAF19167 AK055944 BAG51595 AK127127 BAG54440 AK127656 BAG54544 AK222883 BAD96603 AK296154 BAG58893 AK300097 BAG61898 AK314678 BC111055 AAI11056 BC114440 AAI14441 BC114497 AAI14498 BQ575925 DA382785 DA599419 U70987 AAC51127 XM_011532669 XP_011530971 XM_011532670 XP_011530972 NM_001197260 NP_001184189 NM_001381 NP_001372
Function	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Subcellular Location	Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
Top Pathways	Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DOK1 full length protein - ab112280 from Abcam Category Protein Source Wheat germ Species Human

Human DOK1 peptide - ab39756 from Abcam Category Peptide Species Human

DOK1-Antibody-N-term-Blocking-Peptide - BP7690a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human DOK1 protein - orb244933 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

DOK1 / p62 dok - H00001796-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DOK1 / p62 dok - H00001796-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DOK1 Peptide - 1107P from ProSci Category Peptide Species Human

DOK1 fusion protein - ag12584 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DOK1 fusion protein - ag12189 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

p62Dok(phospho-Tyr362) Antibody Blocking Peptide - GWB-E7365B from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

p62Dok(phospho-Tyr398) Antibody Blocking Peptide - GWB-A683F9 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human DOK1 - DOK1-28084TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human DOK1 - DOK1-619H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Dok-1 (P356) Peptide - BS3649P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Dok-1 (R392) Peptide - BS3650P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Dok-1 (Y362) Peptide - BS4784P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Dok-1 (Y398) Peptide - BS4785P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Docking protein 1(DOK1) - CSB-YP858723HU CSB-BP858723HU CSB-MP858723HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Docking protein 1 - CSB-EP858723HU from Cusabio Category Protein Source E.coli Species Human

p62Dok(phospho-Tyr398) antibody blocking peptide - 51277 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

p62Dok(phospho-Tyr362) antibody blocking peptide - 51276 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

DOK1 Protein - abx163375 from Abbexa Category Protein Species Human, Mouse, Rat

DOK1 / p62 dok - TP317617 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

phospho-Dok1 (Ser-450) Peptide, Peptide - MBS474030 from MyBioSource Category Peptide Prices $130.00 Sizes 50 µg

phospho-Dok1 (Tyr-362) Peptide, Peptide - MBS474031 from MyBioSource Category Peptide Prices $130.00 Sizes 50 µg

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