DOK1

Gene Symbol DOK1
Entrez Gene 1796
Alt Symbol P62DOK
Species Human
Gene Type protein-coding
Description docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Other Description Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62
Swissprots Q53TY2 O43204 Q99704 Q9UHG6
Accessions AAX93224 EAW99612 EAW99613 EAW99614 Q99704 AF035299 AAB88182 AF180527 AAF19167 AK055944 BAG51595 AK127127 BAG54440 AK127656 BAG54544 AK222883 BAD96603 AK296154 BAG58893 AK300097 BAG61898 AK314678 BC111055 AAI11056 BC114440 AAI14441 BC114497 AAI14498 BQ575925 DA382785 DA599419 U70987 AAC51127 XM_011532669 XP_011530971 XM_011532670 XP_011530972 NM_001197260 NP_001184189 NM_001381 NP_001372
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Subcellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
Top Pathways Measles

DOK1-Over-expression-Lysate - LY12171a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DOK1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DOK1 gene

DOK1 293T Cell Transient Overexpression Lysate(Denatured) - H00001796-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

DOK1 293 Cell Lysate - 409358 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

DOK1 Overexpression Lysate (Denatured) - H00001796-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
DOK1 transfected lysate

DOK1 Overexpression Lysate (Native) - NBL1-09977 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DOK1 Overexpression Lysate (Adult Normal) [NBL1-09977] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DOK1.

DOK1 Over-expression Lysate Product - GWB-294517 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human DOK1 Knockdown Stable Cell Line - CSC-DC004483 from Creative biogene

Category Cell Line
Species Human
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