| Gene Symbol |
Amer2
|
| Entrez Gene |
72125
|
| Alt Symbol |
2600011E07Rik, Fam123a
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
APC membrane recruitment 2
|
| Other Description |
APC membrane recruitment protein 2|family with sequence similarity 123, member A|protein FAM123A
|
| Swissprots |
Q8CCJ4 Q7TNC5 Q9D0Q2 Q8K0U9
|
| Accessions |
Q8CCJ4 AK011185 BAB27452 AK032651 BAC27972 AK139177 BAE23912 BC030356 AAH30356 BC056350 AAH56350 CJ122740 XM_006519590 XP_006519653 XM_006519591 XP_006519654 NM_001164705 NP_001158177 NM_028113 NP_082389
|
| Function |
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.
|