| Gene Symbol | Amer2 |
|---|---|
| Entrez Gene | 72125 |
| Alt Symbol | 2600011E07Rik, Fam123a |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | APC membrane recruitment 2 |
| Other Description | APC membrane recruitment protein 2|family with sequence similarity 123, member A|protein FAM123A |
| Swissprots | Q8CCJ4 Q7TNC5 Q9D0Q2 Q8K0U9 |
| Accessions | Q8CCJ4 AK011185 BAB27452 AK032651 BAC27972 AK139177 BAE23912 BC030356 AAH30356 BC056350 AAH56350 CJ122740 XM_006519590 XP_006519653 XM_006519591 XP_006519654 NM_001164705 NP_001158177 NM_028113 NP_082389 |
| Function | Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}. |
MISSION® esiRNA - EMU035651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30950 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30950 from Sigma-Aldrich
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AMER2 siRNA (Mouse) - CRM8707 from Cohesion Biosciences
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AMER2 - MBS8236549 from MyBioSource
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shRNA set against Mouse FAM123A (NM_028113.3) - SHH289369 from Creative biogene
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FAM123A siRNA (m) - sc-108774 from Santa Cruz Biotechnology
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FAM123A shRNA Plasmid (m) - sc-108774-SH from Santa Cruz Biotechnology
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FAM123A shRNA (m) Lentiviral Particles - sc-108774-V from Santa Cruz Biotechnology
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AMER2 shRNA Plasmid (Mouse) - CHM8707 from Cohesion Biosciences
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