| Gene Symbol |
ADRA1B
|
| Entrez Gene |
147
|
| Alt Symbol |
ADRA1, ALPHA1BAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 1B
|
| Other Description |
adrenergic, alpha-1B-, receptor|alpha-1B adrenergic receptor|alpha-1B adrenoceptor|alpha-1B adrenoreceptor|alpha-1B-adrenergic receptor
|
| Swissprots |
B0LPE1 P35368
|
| Accessions |
AAS21324 ABY87520 EAW61572 P35368 AK309989 BC136568 AAI36569 BC136569 AAI36570 BQ576306 BX648936 L31773 AAB59485 U03865 AAB60352 XM_005265818 XP_005265875 XM_005265819 XP_005265876 XM_006714821 XP_006714884 XM_011534435 XP_011532737 XM_011534436 XP_011532738 XM_011534437 XP_011532739 XM_011534438 XP_011532740 XM_011534439 XP_011532741 XM_011534440 XP_011532742 NM_000679 NP_000670
|
| Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
|
| Subcellular Location |
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
|
| Top Pathways |
Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway
|