ADRA1B
| Gene Symbol | ADRA1B |
|---|---|
| Entrez Gene | 147 |
| Alt Symbol | ADRA1, ALPHA1BAR |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenoceptor alpha 1B |
| Other Description | adrenergic, alpha-1B-, receptor|alpha-1B adrenergic receptor|alpha-1B adrenoceptor|alpha-1B adrenoreceptor|alpha-1B-adrenergic receptor |
| Swissprots | B0LPE1 P35368 |
| Accessions | AAS21324 ABY87520 EAW61572 P35368 AK309989 BC136568 AAI36569 BC136569 AAI36570 BQ576306 BX648936 L31773 AAB59485 U03865 AAB60352 XM_005265818 XP_005265875 XM_005265819 XP_005265876 XM_006714821 XP_006714884 XM_011534435 XP_011532737 XM_011534436 XP_011532738 XM_011534437 XP_011532739 XM_011534438 XP_011532740 XM_011534439 XP_011532741 XM_011534440 XP_011532742 NM_000679 NP_000670 |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| Subcellular Location | Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. |
| Top Pathways | Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway |
α 1B -AR CRISPR/Cas9 KO Plasmid (h) - sc-403295 from Santa Cruz Biotechnology
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α 1B -AR HDR Plasmid (h) - sc-403295-HDR from Santa Cruz Biotechnology
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α 1B -AR Double Nickase Plasmid (h) - sc-403295-NIC from Santa Cruz Biotechnology
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α 1B -AR Double Nickase Plasmid (h2) - sc-403295-NIC-2 from Santa Cruz Biotechnology
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α 1B -AR CRISPR Activation Plasmid (h) - sc-403295-ACT from Santa Cruz Biotechnology
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α 1B -AR CRISPR Activation Plasmid (h2) - sc-403295-ACT-2 from Santa Cruz Biotechnology
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α 1B -AR Lentiviral Activation Particles (h) - sc-403295-LAC from Santa Cruz Biotechnology
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α 1B -AR Lentiviral Activation Particles (h2) - sc-403295-LAC-2 from Santa Cruz Biotechnology
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α 1B -AR siRNA (h) - sc-39860 from Santa Cruz Biotechnology
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α 1B -AR shRNA Plasmid (h) - sc-39860-SH from Santa Cruz Biotechnology
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α 1B -AR shRNA (h) Lentiviral Particles - sc-39860-V from Santa Cruz Biotechnology
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alpha-1B Adrenergic R/ADRA1B RNAi - H00000147-R02 from Novus Biologicals
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MISSION® esiRNA - EHU054451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2899 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2899 from Sigma-Aldrich
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ADRA1B siRNA (Human) - CRH0102 from Cohesion Biosciences
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ADRA1B - MBS8217918 from MyBioSource
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shRNA set against Human ADRA1B (NM_000679.3) - SHH232682 from Creative biogene
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shRNA set against Human ADRA1B(NM_000679.3) - SHG043921 from Creative biogene
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ADRA1B shRNA Plasmid (Human) - CHH0102 from Cohesion Biosciences
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ADRA1B miRNA 3'UTR clone - MiUTR1H-00215 from Creative biogene
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