Gene Symbol | METTL21A |
---|---|
Entrez Gene | 151194 |
Alt Symbol | FAM119A, HCA557b, HSPA-KMT |
Species | Human |
Gene Type | protein-coding |
Description | methyltransferase like 21A |
Other Description | HSPA lysine methyltransferase|family with sequence similarity 119, member A|heat shock protein 70kDa lysine (K) methyltransferase|hepatocellular carcinoma-associated antigen 557b|methyltransferase-like protein 21A|protein N-lysine methyltransferase METTL21A|protein-lysine methyltransferase METTL21A |
Swissprots | Q8WXB1 Q96GH6 Q53RV0 Q8N1Z9 |
Accessions | AAX93175 EAW70411 EAW70412 EAW70413 EAW70414 EAW70415 EAW70416 EAW70417 Q8WXB1 AF455817 AAL66295 AI332764 AI363134 AK093812 BAC04229 BC009462 AAH09462 BC033720 AAH33720 BG198655 BG832122 CN367990 XM_005246336 XP_005246393 XM_005246337 XP_005246394 XM_005246338 XP_005246395 XM_005246339 XP_005246396 XM_005246340 XP_005246397 XM_005246341 XP_005246398 XM_006712327 XP_006712390 XM_006712329 XP_006712392 XM_011510724 XP_011509026 XM_011510725 XP_011509027 XM_011510726 XP_011509028 XM_011510727 XP_011509029 XM_011510728 XP_011509030 XM_011510729 XP_011509031 XM_011510730 XP_011509032 XM_011510731 XP_011509033 XM_011510732 XP_011509034 NM_001127395 NP_001120867 NM_001308021 NP_001294950 NM_145280 NP_660323 |
Function | Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys- 564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys- 561' in HSPA8. {ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:23921388}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23349634}. |
METTL21A CRISPR/Cas9 KO Plasmid (h) - sc-418251 from Santa Cruz Biotechnology
|
||||||||
METTL21A HDR Plasmid (h) - sc-418251-HDR from Santa Cruz Biotechnology
|
||||||||
METTL21A Double Nickase Plasmid (h) - sc-418251-NIC from Santa Cruz Biotechnology
|
||||||||
METTL21A Double Nickase Plasmid (h2) - sc-418251-NIC-2 from Santa Cruz Biotechnology
|
||||||||
METTL21A CRISPR Activation Plasmid (h) - sc-418251-ACT from Santa Cruz Biotechnology
|
||||||||
METTL21A CRISPR Activation Plasmid (h2) - sc-418251-ACT-2 from Santa Cruz Biotechnology
|
||||||||
METTL21A Lentiviral Activation Particles (h) - sc-418251-LAC from Santa Cruz Biotechnology
|
||||||||
METTL21A Lentiviral Activation Particles (h2) - sc-418251-LAC-2 from Santa Cruz Biotechnology
|
||||||||
METTL21A siRNA (h) - sc-94929 from Santa Cruz Biotechnology
|
||||||||
METTL21A shRNA Plasmid (h) - sc-94929-SH from Santa Cruz Biotechnology
|
||||||||
METTL21A shRNA (h) Lentiviral Particles - sc-94929-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU049041 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8140 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8140 from Sigma-Aldrich
|
||||||||
METTL21A siRNA (Human) - CRJ5686 from Cohesion Biosciences
|
||||||||
shRNA set against Human METTL21A (NM_145280.4) - SHH340759 from Creative biogene
|
||||||||
Human METTL21A siRNA - orb276187 from Biorbyt
|
||||||||
METTL21A shRNA Plasmid (Human) - CHJ5686 from Cohesion Biosciences
|
||||||||
METTL21A miRNA 3'UTR clone - MiUTR4H-TG03355 from Creative biogene
|