| Gene Symbol |
SOX2
|
| Entrez Gene |
6657
|
| Alt Symbol |
ANOP3, MCOPS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRY (sex determining region Y)-box 2
|
| Other Description |
SRY-related HMG-box gene 2|transcription factor SOX-2|transcription factor SOX2
|
| Swissprots |
Q14537 P48431
|
| Accessions |
AJF45877 AJF45878 AJF45879 AJF45880 AJF45899 AJF45900 AJF45901 AJF45902 AJF45903 AJF45904 AJF45905 AJF45906 AJF45907 AJF45908 AJF45909 AJF45910 AJF45911 AJF45912 EAW78354 P48431 AK312595 BAG35487 AW016610 AW163619 BC013923 AAH13923 BF305585 BM668019 BM722297 CN430685 DA388996 EU446654 ABZ92183 KM822781 AJF45876 L07335 AAA35997 Z31560 CAA83435 NM_003106 NP_003097
|
| Function |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: SOX2 Overexpression Lysate (Adult Normal) [NBL1-16348] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SOX2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/966_SOX2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16348-img0002.jpg)