SOX2

Gene Symbol SOX2
Entrez Gene 6657
Alt Symbol ANOP3, MCOPS3
Species Human
Gene Type protein-coding
Description SRY (sex determining region Y)-box 2
Other Description SRY-related HMG-box gene 2|transcription factor SOX-2|transcription factor SOX2
Swissprots Q14537 P48431
Accessions AJF45877 AJF45878 AJF45879 AJF45880 AJF45899 AJF45900 AJF45901 AJF45902 AJF45903 AJF45904 AJF45905 AJF45906 AJF45907 AJF45908 AJF45909 AJF45910 AJF45911 AJF45912 EAW78354 P48431 AK312595 BAG35487 AW016610 AW163619 BC013923 AAH13923 BF305585 BM668019 BM722297 CN430685 DA388996 EU446654 ABZ92183 KM822781 AJF45876 L07335 AAA35997 Z31560 CAA83435 NM_003106 NP_003097
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells

Sox-2 CRISPR/Cas9 KO Plasmid (h) - sc-400050 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 HDR Plasmid (h) - sc-400050-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 Double Nickase Plasmid (h) - sc-400050-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 Double Nickase Plasmid (h2) - sc-400050-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 CRISPR Activation Plasmid (h) - sc-400050-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 CRISPR Activation Plasmid (h2) - sc-400050-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 Lentiviral Activation Particles (h) - sc-400050-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 Lentiviral Activation Particles (h2) - sc-400050-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 siRNA (h) - sc-38408 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sox-2 shRNA Plasmid (h) - sc-38408-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sox-2 shRNA (h) Lentiviral Particles - sc-38408-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2136 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2136 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08442 from Sigma-Aldrich

Category miRNA

SOX2 siRNA (Human) - CRH4537 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOX2 RNAi - H00006657-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SOX2 - MBS828880 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sox-2 CRISPR/Cas9 KO Plasmid (h2) - sc-400050-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-2 HDR Plasmid (h2) - sc-400050-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SOX2 (NM_003106.3) - SHH415396 from Creative biogene

Category siRNA
Species Reactivities Human

SOX2 shRNA Plasmid (Human) - CHH4537 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SOX2 miRNA 3'UTR clone - MiUTR3H-02133 from Creative biogene

Species Reactivities Human
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