| Gene Symbol |
PRSS8
|
| Entrez Gene |
5652
|
| Alt Symbol |
CAP1, PROSTASIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protease, serine, 8
|
| Other Description |
channel-activating protease 1|prostasin|serine protease 8
|
| Swissprots |
B4DWP2 Q16651 Q9UCA3
|
| Accessions |
AAB19071 EAW52155 EAW52156 Q16651 AK296656 BAG59253 AK301619 BAG63104 AK309955 BC001462 AAH01462 DQ892160 ABM83086 DQ895354 ABM86280 L41351 AAC41759 NM_002773 NP_002764
|
| Function |
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269|PubMed:15246975, ECO:0000269|PubMed:15474520}.
|
| Subcellular Location |
Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
|
| Tissue Specificity |
Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.
|