APOBEC3A

Gene Symbol APOBEC3A
Entrez Gene 200315
Alt Symbol A3A, ARP3, PHRBN, bK150C2.1
Species Human
Gene Type protein-coding
Description apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
Other Description DNA dC->dU-editing enzyme APOBEC-3A|phorbolin 1|phorbolin-1|probable DNA dC->dU-editing enzyme APOBEC-3A
Swissprots Q5JZ93 A0AVM1 P31941 Q12807 Q9UH18
Accessions EAW60278 P31941 BC126416 AAI26417 BC144146 AAI44147 BI029063 CR456393 CAG30279 CU012950 CAK54381 CU013238 CAK54680 DB322320 HQ258100 ADR82854 U03891 AAA03706 NM_001270406 NP_001257335 NM_145699 NP_663745
Function DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20308164}.

APOBEC3A (D-23) - sc-130688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
APOBEC3A (D-23): sc-130688. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

APOBEC3A/B (D-15) - sc-86289 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
APOBEC3A/B (D-15): sc-86289. Western blot analysis of APOBEC3A expression in non-transfected: sc-117752 (A) and human APOBEC3A transfected: sc-127982 (B) 293T whole cell lysates.

APOBEC3A/B (F-18) - sc-86291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-PHO1 antibody - ab38641 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PHO1 antibody (ab38641) + jurkat cell lysate

Anti-PHO1 antibody - ab92805 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PHO1 antibody (ab92805) at 1/500 dilutionLane 1 : extracts from Jurkat cellsLane 2 : extracts from Jurkat cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-PHO1 antibody - ab134834 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry analysis of formalin fixed, paraffin embedded Human tonsil tissue labelling PHO1 with ab134834 at 3.75 µg/ml.

Anti-PHO1 antibody [EPR9165(2)] - ab150369 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9165(2)
Overlay histogram showing THP1 cells stained with ab150369 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% human serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab150369, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-APOBEC3A Antibody (aa20-49, AP) - LS-C251537 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49, APC) - LS-C251538 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49, Biotin) - LS-C251539 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49, FITC) - LS-C251540 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49, PE) - LS-C251541 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49, Azide-free, HRP) - LS-C251542 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (N-Terminus, APC) - LS-C275176 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (N-Terminus, AP) - LS-C275175 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa27-76) - LS-C120249 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using APOBEC3A Antibody. The lane on the right is treated with the synthesized peptide.

Anti-APOBEC3A Antibody (N-Terminus, Biotin) - LS-C275177 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49) - LS-C157553 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
APOBEC3A Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The APOBEC3A antibody detected the APOBEC3A protein (arrow).

Anti-APOBEC3A Antibody (aa1-30) - LS-C98892 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with PHO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-APOBEC3A Antibody (N-Terminus, FITC) - LS-C275178 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (N-Terminus, Azide-free, HRP) - LS-C275179 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (N-Terminus, PE) - LS-C275180 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa67-112) - LS-C313667 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (aa20-49) - LS-C319540 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3A Antibody (N-Terminus) - LS-C326861 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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