APOBEC3A

Gene Symbol	APOBEC3A
Entrez Gene	200315
Alt Symbol	A3A, ARP3, PHRBN, bK150C2.1
Species	Human
Gene Type	protein-coding
Description	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
Other Description	DNA dC->dU-editing enzyme APOBEC-3A|phorbolin 1|phorbolin-1|probable DNA dC->dU-editing enzyme APOBEC-3A
Swissprots	Q5JZ93 A0AVM1 P31941 Q12807 Q9UH18
Accessions	EAW60278 P31941 BC126416 AAI26417 BC144146 AAI44147 BI029063 CR456393 CAG30279 CU012950 CAK54381 CU013238 CAK54680 DB322320 HQ258100 ADR82854 U03891 AAA03706 NM_001270406 NP_001257335 NM_145699 NP_663745
Function	DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
Subcellular Location	Nucleus. Cytoplasm.
Tissue Specificity	Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20308164}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

APOBEC3A Antibody Blocking Peptide - LS-E2515 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APOBEC3A Antibody Blocking Peptide - LS-E26577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APOBEC3A Peptide - P0356 from Novus Biologicals Category Peptide Species Human

PHO1-Antibody-N-term-Blocking-Peptide - BP1354a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APOBEC3A blocking peptide - GTX88838-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ACTR3 protein (His tag) - 80R-3970 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

APOBEC3A Blocking Peptide - abx064084 from Abbexa Category Peptide Species Human, Mouse, Rat

ARP3 Blocking Peptide - abx063647 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Rabbit, Zebrafish

PHO1 Peptide - AC21-1413-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

APOBEC3A Peptide - 46-697P from ProSci Category Peptide Species Human

APOBEC3A fusion protein - Ag18845 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

APOBEC3A fusion protein - ag18969 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human APOBEC3A, GST-tagged - APOBEC3A-9753H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human APOBEC3A_B - APOBEC3A_B-1284H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Human ACTR3 Protein (His & GST Tag) - 15179-H20B-100 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

APOBEC3A Blocking Peptide - CBP2890 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PHO1 Peptide - BS5613P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human DNA dC->dU-editing enzyme APOBEC-3A - CSB-EP001921HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3A(APOBEC3A) - CSB-YP001921HU CSB-EP001921HU CSB-BP001921HU CSB-MP001921HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Arp3 (1-110) - sc-4661 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

Arp3 (C-terminal region) - AX4585 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

APOBEC3A - TP320995 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DNA dC->dU-editing enzyme APOBEC-3A, Recombinant Protein - MBS958677 from MyBioSource Category Protein Prices $110.00, $190.00, $460.00, $750.00, $945.00, $1,170.00, $1,170.00, $1,180.00, $1,415.00, $1,875.00, $1,875.00 Sizes 10 µg (E-Coli), 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Phorbolin 1/APOBEC3A, Peptide - MBS425843 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human APOBEC3A protein, MYC/DDK-tagged - APOBEC3A-15H from Creative Biomart Category Protein Source HEK293 Species Human

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