PI4K2A

Gene Symbol PI4K2A
Entrez Gene 55361
Alt Symbol PI4KII, PIK42A
Species Human
Gene Type protein-coding
Description phosphatidylinositol 4-kinase type 2 alpha
Other Description phosphatidylinositol 4-kinase type 2-alpha|phosphatidylinositol 4-kinase type II (PI4KII)|phosphatidylinositol 4-kinase type II-alpha
Swissprots Q9NSG8 D3DR59 Q9BTU6
Accessions EAW49906 EAW49907 Q9BTU6 AF070611 AJ303098 CAC38065 AK023236 AK024317 AK309343 AL353952 CAB89254 BC003167 AAH03167 BT007330 AAP35994 DQ893537 ABM84463 DQ893758 ABM84684 NM_018425 NP_060895
Function Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:22535966}; Lipid-anchor {ECO:0000269|PubMed:22535966}. Membrane raft {ECO:0000269|PubMed:11279162}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6}. Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Endosome {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:23146885}. Cytoplasmic vesicle {ECO:0000269|PubMed:16443754}. Membrane {ECO:0000269|PubMed:24675427}; Lipid-anchor {ECO:0000269|PubMed:24675427}. Cell membrane {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754}. Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP-3-complexes- dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity). Found in sub
Tissue Specificity Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. {ECO:0000269|PubMed:11279162}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

PI 4-kinase II α (B-5) - sc-390026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 4-kinase II α (B-5): sc-390026. Western blot analysis of PI 4-kinase II α expression in HL-60 (A) and Caki-1 (B) whole cell lysates.

PI 4-kinase II α (H-40) - sc-292944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 4-kinase II α (H-40): sc-292944. Western blot analysis of PI 4-kinase II α expression in AMJ2-C8 whole cell lysate.

PI 4-kinase II α (P-15) - sc-165235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 4-kinase II α (N-24) - sc-130231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PI 4-kinase II α (N-24):sc-130231. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

PI 4-kinase II α (C-12) - sc-165233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PI4K2A antibody - ab68732 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PI4K2A antibody (ab68732) at 1/500 dilutionLane 1 : PI4K2A transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP

Anti-PI4K2A antibody - N-terminal - ab71824 from Abcam

Prices $313.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PI4K2A antibody - N-terminal (ab71824) at 1/100 dilution + HL60 cell lysate at 12.5 µgSecondaryHRP-anti-rabbit

Anti-PI4K2A / PI4KII Antibody (aa1-30, FITC) - LS-C280954 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa386-415) - LS-C324018 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30, PE) - LS-C280956 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30, Azide-free, HRP) - LS-C280955 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30) - LS-C328244 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415) - LS-C163708 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PI4K2A Antibody western blot of CEM cell line lysates (35 ug/lane). The PI4K2A antibody detected the PI4K2A protein (arrow).

Anti-PI4K2A / PI4KII Antibody - LS-C346257 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Western blot blot of extracts of HL60 cell line, using PI4K2A antibody.

Anti-PI4K2A / PI4KII Antibody (aa1-30) - LS-C101106 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PI4K2A / PI4KII Antibody (N-Terminus) - LS-C209417 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, AP) - LS-C266296 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, APC) - LS-C266298 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, FITC) - LS-C266300 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, PE) - LS-C266302 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, Biotin) - LS-C266299 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30, AP) - LS-C280951 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa387-415, Azide-free, HRP) - LS-C266301 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30, APC) - LS-C280952 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2A / PI4KII Antibody (aa1-30, Biotin) - LS-C280953 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more