PI4K2A

Gene Symbol	PI4K2A
Entrez Gene	55361
Alt Symbol	PI4KII, PIK42A
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol 4-kinase type 2 alpha
Other Description	phosphatidylinositol 4-kinase type 2-alpha|phosphatidylinositol 4-kinase type II (PI4KII)|phosphatidylinositol 4-kinase type II-alpha
Swissprots	Q9NSG8 D3DR59 Q9BTU6
Accessions	EAW49906 EAW49907 Q9BTU6 AF070611 AJ303098 CAC38065 AK023236 AK024317 AK309343 AL353952 CAB89254 BC003167 AAH03167 BT007330 AAP35994 DQ893537 ABM84463 DQ893758 ABM84684 NM_018425 NP_060895
Function	Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:22535966}; Lipid-anchor {ECO:0000269|PubMed:22535966}. Membrane raft {ECO:0000269|PubMed:11279162}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6}. Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Endosome {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:23146885}. Cytoplasmic vesicle {ECO:0000269|PubMed:16443754}. Membrane {ECO:0000269|PubMed:24675427}; Lipid-anchor {ECO:0000269|PubMed:24675427}. Cell membrane {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754}. Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP-3-complexes- dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity). Found in sub
Tissue Specificity	Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. {ECO:0000269|PubMed:11279162}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI4K2A full length protein - ab102109 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human PI4K2A full length protein - ab163083 from Abcam Category Protein Source Wheat germ Species Human

Human PI4K2A protein fragment - ab163084 from Abcam Category Protein Source Wheat germ Species Human

PI4K2A / PI4KII Antibody Blocking Peptide - LS-E4584 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI4K2A / PI4KII Antibody Blocking Peptide - LS-E9440 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PI4K2A Protein - H00055361-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PI4K2A Recombinant Protein - H00055361-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

PI4K2A Peptide - P3016 from Novus Biologicals Category Peptide Species Human

PI4K2A-Antibody-C-term-Blocking-Peptide - BP16933b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI4K2A-Antibody-N-term-D2-Blocking-Peptide - BP7575d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI4K2A-PI4K-II-Antibody-N-term-Blocking-peptide - BP8032a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI4K2A - H00055361-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PI4K2A - H00055361-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PI4K2A - H00055361-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PI4K2A fusion protein - Ag7845 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PI4K2A fusion protein - ag7564 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PI4K2A - PI4K2A-30365TH from Creative Biomart Category Protein Source Baculovirus infected sf9 cells

Recombinant Human PI4K2A, His-tagged - PI4K2A-1698H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PI4K2A, GST-tagged - PI4K2A-1075H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human PI4K2A (Active), GST-tagged - PI4K2A-1450H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human Phosphatidylinositol 4-kinase type 2-alpha(PI4K2A) - CSB-YP887123HU CSB-EP887123HU CSB-BP887123HU CSB-MP887123HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PI4K2A - TP301367 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A), Recombinant Protein - MBS1331305 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,480.00, $1,480.00, $2,065.00, $2,065.00, $2,530.00, $2,530.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PI4K2A Peptide, Human - M34GP11737H from Creative Peptides Category Peptide Source Synthetic. Species Human

PI4K2A Recombinant Protein Antigen - NBP2-57410PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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